DegronMD

Uniprot ID: P16150

Source protein: Leukosialin

Source gene: SPN

Class: DEG_SPOP_SBC_1

Location: 234:238

E3 ligase: SPOP

DEGRON score: 0.8906

ASA_SCORE: 89.24

COIL: 0.9184

CONS_SCORE: 0.6167

DSS_SCORE: 0.519

HELIX: 0.0234

FCONS_SCORE: 1.2231

RIG_SCORE: 0.6424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P248T	TCGA-A5-A0GB	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.0556
p.P248T	DO41434	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.0556
p.R246W	TCGA-CA-6717	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.1111
p.R246W	DO8264	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.R246Q	TCGA-DX-A2IZ	SARC	TCGA	PTTST	DEG_SPOP_SBC_1	0.1111
p.R246Q	TCGA-NH-A5IV	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.1111
p.R246Q	DO49095	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.R246Q	DO219961	SARC	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.S224F	DO225215	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	0.0556
p.S224F	DO227836	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	0.0556
p.S225R	DO234285	ESAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00455	Pancreatic Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00884	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00885	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00869	Non-Cancerous	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S225R	SIDM00883	Non-Cancerous	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.V226L	DO228971	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.N239S	DO50889	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons