DegronMD - Q8IZA0(KIAA0319L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I199V	TCGA-43-A474	LUSC	TCGA	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5965
p.I199V	DO45490	LUSC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5965
p.D435Y	TCGA-62-A46Y	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.D435Y	DO48883	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.R167I	TCGA-91-6836	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.R167I	DO23854	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.L618Q	TCGA-A2-A25A	BRCA	TCGA	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.3056
p.A282D	TCGA-A5-A1OF	UCEC	TCGA	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.1111
p.A282D	DO42568	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.1111
p.T434A	TCGA-B5-A11E	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1111
p.T434A	DO41644	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.1111
p.D429Y	TCGA-BS-A0UF	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.D429Y	DO41488	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.A603G	TCGA-CV-7102	HNSC	TCGA	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0556
p.A603P	TCGA-CV-7102	HNSC	TCGA	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0556
p.L611I	TCGA-D3-A1QA	SKCM	TCGA	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.2778
p.S295F	TCGA-DA-A95X	SKCM	TCGA	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation altering degron motif	0.7982
p.S295F	DO219480	SKCM	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation altering degron motif	0.7982
p.S413P	TCGA-EO-A22X	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.S413P	DO43907	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.G604D	TCGA-FI-A2D5	UCEC	TCGA	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0833
p.I419N	TCGA-OL-A5D7	BRCA	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.I419N	DO44113	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.25
p.S420C	TCGA-VS-A953	CESC	TCGA	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.S420C	DO219727	CESC	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.E194K	DO834	BLCA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.3056
p.H184Y	DO218984	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1389
p.A298V	DO222842	COCA	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.25
p.L187F	DO228618	GACA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1111
p.L187F	DO228618	GACA	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.L187F	DO37707	SKCM	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1111
p.L187F	DO37707	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.D168Y	DO10880	GBM	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1944
p.R305W	DO20102	KIRC	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.0556
p.P304T	DO228948	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.0833
p.A424E	DO229029	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7701
p.T289N	DO229026	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.3056
p.T426K	DO229031	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7306
p.H288Q	DO229037	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.2778
p.L170I	DO229041	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.T196I	DO52664	MALY	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7078
p.R423Q	DO51762	STAD	ICGC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7329
p.F291S	DO229272	THCA	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation altering degron motif	0.7982
p.S210C	DO229248	THCA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.0833
p.R305Q	DO41638	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.0556
p.A206T	DO42512	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1944
p.D205G	DO42745	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation substituting flanking lysine	0.3333
p.F291V	DO41361	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation altering degron motif	0.7068
p.D205N	DO41379	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation substituting flanking lysine	0.3333
p.D435V	SIDM01197	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.D435V	ACH-000722	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.D435V	SNU-C1	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.0833
p.T197I	SIDM00860	Head and Neck Carcinoma	GDSC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7078
p.T197I	ACH-000846	Head and Neck Cancer	CCLE	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7078
p.T197I	FADU	upper aerodigestive tract	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7078
p.I183M	SIDM00445	Esophageal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.I183M	ACH-002292	Esophageal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.I183M	OACp4C	oesophagus	COSMIC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.V195I	SIDM00217	Colorectal Carcinoma	GDSC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5965
p.V195I	ACH-000999	Colon/Colorectal Cancer	CCLE	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5965
p.V195I	SNU-1040	large intestine	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5965
p.Q180E	SIDM00534	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.Q180E	ACH-000986	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.Q180E	HT-115	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.S623G	SIDM00118	Colorectal Carcinoma	GDSC	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.1667
p.S623G	ACH-001081	Colon/Colorectal Cancer	CCLE	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.1667
p.S623G	HCC2998	large intestine	COSMIC	VDSTT	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.1667
p.P302Q	SIDM00785	Acute Myeloid Leukemia	GDSC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.1389
p.P302Q	SIDM01318	Hepatocellular Carcinoma	GDSC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.1389
p.P302Q	KG-1	haematopoietic and lymphoid tissue	COSMIC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.1389
p.A206V	SNU-175	large intestine	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1944
p.P286S	KM12	large intestine	COSMIC	PTPQAS	DEG_SCF_FBW7_1	290:295	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0319L

UniProt ID: Q8IZA0

Entrez ID: 79932

Protein name: Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0319L in