DegronMD

Uniprot ID: Q8IZA0

Source protein: Dyslexia-associated protein KIAA0319-like protein

Source gene: KIAA0319L

Class: DEG_SCF_FBW7_1

Location: 290:295

E3 ligase: FBXW7

DEGRON score: 0.9502

ASA_SCORE: 67.75

COIL: 0.7342

CONS_SCORE: 0.3176

DSS_SCORE: 0.4165

HELIX: 0.0728

FCONS_SCORE: 0.9855

RIG_SCORE: 0.6916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A282D	TCGA-A5-A1OF	UCEC	TCGA	PTPQAS	DEG_SCF_FBW7_1	0.1111
p.A282D	DO42568	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.1111
p.S295F	TCGA-DA-A95X	SKCM	TCGA	PTPQAS	DEG_SCF_FBW7_1	0.7982
p.S295F	DO219480	SKCM	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.7982
p.A298V	DO222842	COCA	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.25
p.R305W	DO20102	KIRC	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.0556
p.P304T	DO228948	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.0833
p.T289N	DO229026	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.3056
p.H288Q	DO229037	LICA	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.2778
p.F291S	DO229272	THCA	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.7982
p.R305Q	DO41638	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.0556
p.F291V	DO41361	UCEC	ICGC	PTPQAS	DEG_SCF_FBW7_1	0.7068
p.P302Q	SIDM00785	Acute Myeloid Leukemia	GDSC	PTPQAS	DEG_SCF_FBW7_1	0.1389
p.P302Q	SIDM01318	Hepatocellular Carcinoma	GDSC	PTPQAS	DEG_SCF_FBW7_1	0.1389
p.P302Q	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPQAS	DEG_SCF_FBW7_1	0.1389
p.P286S	KM12	large_intestine	COSMIC	PTPQAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SCF_FBW7_1	290:295	PTPQAS	FBXW7	0.9502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons