DegronMD

Uniprot ID: Q8IZA0

Source protein: Dyslexia-associated protein KIAA0319-like protein

Source gene: KIAA0319L

Class: DEG_SCF_FBW7_1

Location: 195:201

E3 ligase: FBXW7

DEGRON score: 0.9253

ASA_SCORE: 62.2

COIL: 0.6256

CONS_SCORE: 0.2857

DSS_SCORE: 0.5888

HELIX: 0.0186

FCONS_SCORE: 0.9445

RIG_SCORE: 0.7455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I199V	TCGA-43-A474	LUSC	TCGA	VVTPIVT	DEG_SCF_FBW7_1	0.5965
p.I199V	DO45490	LUSC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.5965
p.E194K	DO834	BLCA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.3056
p.L187F	DO228618	GACA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.1111
p.L187F	DO37707	SKCM	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.1111
p.T196I	DO52664	MALY	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.7078
p.S210C	DO229248	THCA	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.0833
p.A206T	DO42512	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.1944
p.D205G	DO42745	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.3333
p.D205N	DO41379	UCEC	ICGC	VVTPIVT	DEG_SCF_FBW7_1	0.3333
p.T197I	SIDM00860	Head and Neck Carcinoma	GDSC	VVTPIVT	DEG_SCF_FBW7_1	0.7078
p.T197I	ACH-000846	Head and Neck Cancer	CCLE	VVTPIVT	DEG_SCF_FBW7_1	0.7078
p.T197I	FADU	upper_aerodigestive_tract	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	0.7078
p.V195I	SIDM00217	Colorectal Carcinoma	GDSC	VVTPIVT	DEG_SCF_FBW7_1	0.5965
p.V195I	ACH-000999	Colon/Colorectal Cancer	CCLE	VVTPIVT	DEG_SCF_FBW7_1	0.5965
p.V195I	SNU-1040	large_intestine	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	0.5965
p.A206V	SNU-175	large_intestine	COSMIC	VVTPIVT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SCF_FBW7_1	195:201	VVTPIVT	FBXW7	0.9253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons