DegronMD

Uniprot ID: Q8IZA0

Source protein: Dyslexia-associated protein KIAA0319-like protein

Source gene: KIAA0319L

Class: DEG_SPOP_SBC_1

Location: 613:617

E3 ligase: SPOP

DEGRON score: 0.9603

ASA_SCORE: 49.58

COIL: 0.4418

CONS_SCORE: 0.5141

DSS_SCORE: 0.6207

HELIX: 0.006

FCONS_SCORE: 0.8752

RIG_SCORE: 0.7223

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L618Q	TCGA-A2-A25A	BRCA	TCGA	VDSTT	DEG_SPOP_SBC_1	0.3056
p.A603G	TCGA-CV-7102	HNSC	TCGA	VDSTT	DEG_SPOP_SBC_1	0.0556
p.A603P	TCGA-CV-7102	HNSC	TCGA	VDSTT	DEG_SPOP_SBC_1	0.0556
p.L611I	TCGA-D3-A1QA	SKCM	TCGA	VDSTT	DEG_SPOP_SBC_1	0.2778
p.G604D	TCGA-FI-A2D5	UCEC	TCGA	VDSTT	DEG_SPOP_SBC_1	0.0833
p.S623G	SIDM00118	Colorectal Carcinoma	GDSC	VDSTT	DEG_SPOP_SBC_1	0.1667
p.S623G	ACH-001081	Colon/Colorectal Cancer	CCLE	VDSTT	DEG_SPOP_SBC_1	0.1667
p.S623G	HCC2998	large_intestine	COSMIC	VDSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	613:617	VDSTT	SPOP	0.9603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons