DegronMD

Uniprot ID: Q99715

Source protein: Collagen alpha-1

Source gene: COL12A1

Class: DEG_SPOP_SBC_1

Location: 825:829

E3 ligase: SPOP

DEGRON score: 0.9873

ASA_SCORE: 55.68

COIL: 0.7598

CONS_SCORE: 0.5304

DSS_SCORE: 0.5341

HELIX: 0.0192

FCONS_SCORE: 0.9986

RIG_SCORE: 0.7343

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V822F	TCGA-86-8073	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.25
p.V822F	DO23624	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.25
p.P838T	TCGA-A6-5661	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.P838T	DO8634	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.K831T	TCGA-AA-3848	COAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.2778
p.K831T	DO9740	COAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.2778
p.T827M	TCGA-AN-A049	BRCA	TCGA	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	DO4305	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00373	Endometrial Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00578	Neuroblastoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01197	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00304	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00592	Oral Cavity Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00217	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00604	Oral Cavity Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01498	Acute Myeloid Leukemia	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01779	Gastric Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM00016	Neuroblastoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.T827M	SIDM01442	Glioma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7423
p.P825H	TCGA-BR-6452	STAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.7694
p.P825H	TCGA-EE-A3AD	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	0.7694
p.P825H	DO37707	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.7694
p.P825H	DO38404	STAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.7694
p.G839R	TCGA-D3-A1Q5	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	0.0556
p.G839R	DO37827	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.0556
p.M830T	TCGA-DD-A3A9	LIHC	TCGA	PTTST	DEG_SPOP_SBC_1	0.3056
p.M830T	DO44888	LIHC	ICGC	PTTST	DEG_SPOP_SBC_1	0.3056
p.P838Q	DO229022	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.P817T	SIDM00741	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1111
p.P817T	ACH-000431	Lung Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1111
p.P817T	NCI-H1694	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1111
p.W834S	SIDM00966	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1944
p.W834S	ACH-002182	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1944
p.W834S	OVCA433	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1944
p.S837N	LS-411N	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1111
p.P819S	SNU-1040	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.G822V	NCI-H2196	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTST

Degron related mutations and impact score

Drug responses associated with COL12A1 mutations

All proteins holding degron of PTTST