DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTTST
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
3827:3831
E3 ligase:
SPOP
DEGRON score:
0.5591
ASA_SCORE:
88.44
COIL:
0.9054
CONS_SCORE:
0.3503
DSS_SCORE:
0.626
HELIX:
0.0232
FCONS_SCORE:
1.2408
RIG_SCORE:
0.5778
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
885:889
PTTST
SPOP
0.9985
More...
P16070
CD44 antigen
DEG_SPOP_SBC_1
527:531
PTTST
SPOP
0.9979
More...
P16150
Leukosialin
DEG_SPOP_SBC_1
234:238
PTTST
SPOP
0.8906
More...
P51532
Transcription activator BRG1
DEG_SPOP_SBC_1
1424:1428
PTTST
SPOP
0.6708
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3128:3132
PTTST
SPOP
0.5488
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3811:3815
PTTST
SPOP
0.6407
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3827:3831
PTTST
SPOP
0.5591
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1621:1625
PTTST
SPOP
0.9682
More...
Q6ZSZ6
Teashirt homolog 1
DEG_SPOP_SBC_1
170:174
PTTST
SPOP
0.7765
More...
Q8IZA0
Dyslexia-associated protein KIAA0319-like protein
DEG_SPOP_SBC_1
422:426
PTTST
SPOP
0.7723
More...
Q8N3K9
Cardiomyopathy-associated protein 5
DEG_SPOP_SBC_1
1097:1101
PTTST
SPOP
0.9044
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12198:12202
PTTST
SPOP
0.9133
More...
Q96GD3
Polycomb protein SCMH1
DEG_SPOP_SBC_1
330:334
PTTST
SPOP
0.7052
More...
Q99607
ETS-related transcription factor Elf-4
DEG_SPOP_SBC_1
375:379
PTTST
SPOP
0.9537
More...
Q99715
Collagen alpha-1
DEG_SPOP_SBC_1
825:829
PTTST
SPOP
0.9873
More...
A6NHQ4
Elongin BC and Polycomb repressive complex 2-associated protein
DEG_SPOP_SBC_1
308:312
PTTST
SPOP
0.9826
More...