DegronMD - O60312(ATP10A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1329C	TCGA-06-0140	GBM	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2222
p.R1329C	TCGA-AD-5900	COAD	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2222
p.R1329C	DO8514	COAD	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2222
p.R1329C	DO44409	GBM	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2222
p.S961T	TCGA-24-1436	OV	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.6005
p.S961T	DO32656	OV	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.6005
p.R1342M	TCGA-33-4586	LUSC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.25
p.R1342M	DO27318	LUSC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.25
p.R968H	TCGA-33-AASI	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	TCGA-BR-8591	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	TCGA-CN-6992	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	TCGA-DC-6681	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO234213	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO233254	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO14606	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO219129	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO36467	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.R968H	DO47973	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1944
p.P960H	TCGA-37-A5EL	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.6583
p.P960H	DO223718	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.6583
p.S971N	TCGA-51-4081	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.S971N	DO26544	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.M952I	TCGA-55-8507	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.M952I	DO45412	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.P960T	TCGA-56-6546	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.5919
p.P960T	DO26542	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.5919
p.S971I	TCGA-A5-A0G1	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.S971I	DO42472	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.P959Q	TCGA-AG-A01W	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7035
p.P959Q	DO36382	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7035
p.K1332N	TCGA-AP-A056	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.3056
p.K1332N	TCGA-BR-8487	STAD	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.3056
p.K1332N	DO47867	STAD	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.3056
p.K1332N	DO43971	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.3056
p.P1331L	TCGA-B5-A3FC	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2778
p.P1331L	DO41871	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2778
p.V950L	TCGA-BK-A6W3	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.V950L	DO50076	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.A1326S	TCGA-C4-A0F0	BLCA	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1389
p.A1326S	DO520	BLCA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1389
p.V973M	TCGA-CM-4750	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.V973M	DO9298	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.V973M	SIDM01266	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.F1325V	TCGA-EO-A22U	UCEC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1111
p.F1325V	DO43755	UCEC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1111
p.S956Y	TCGA-EY-A1G8	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.S956Y	DO43578	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.K1345N	TCGA-FU-A3HZ	CESC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation substituting flanking lysine	0.2778
p.K1345N	DO6308	CESC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation substituting flanking lysine	0.2778
p.S961A	TCGA-L5-A4OW	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7588
p.S956C	TCGA-P5-A5EV	LGG	TCGA	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.S956C	DO50160	LGG	ICGC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.H1338N	TCGA-X6-A7WA	SARC	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.6312
p.H1338N	DO220312	SARC	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.6312
p.G1335E	TCGA-XF-AAN0	BLCA	TCGA	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.7199
p.G1335E	DO51941	BLCA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.7199
p.S1334W	DO233235	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.7874
p.E1337K	DO233731	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.591
p.S1334L	DO233903	GACA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.7667
p.S1334L	DO36556	READ	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation altering degron motif	0.7667
p.R1329S	DO229045	LICA	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2222
p.L1330H	DO45139	LIRI	ICGC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.25
p.S956F	SIDM02044	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.25
p.R969K	SIDM02022	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1667
p.T962M	SIDM00705	Non-Cancerous	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7423
p.T962M	SIDM00087	Plasma Cell Myeloma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7423
p.T962M	SIDM00706	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7423
p.T962M	SIDM00732	Glioblastoma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7423
p.T962M	SIDM00720	Mesothelioma	GDSC	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7423
p.E1323D	SIDM00193	Colorectal Carcinoma	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.0556
p.E1323D	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.0556
p.E1323D	SNU-81	large intestine	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.0556
p.G1328A	SIDM00875	Breast Carcinoma	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1944
p.G1328A	ACH-000624	Breast Cancer	CCLE	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1944
p.G1328A	HCC1806	breast	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.1944
p.G1341W	SIDM00959	Acute Myeloid Leukemia	GDSC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2778
p.G1341W	CMK	haematopoietic and lymphoid tissue	COSMIC	DSGTEHS	DEG_SCF_TRCP1_1	1333:1339	Mutation rewiring degron network	0.2778
p.K949N	ACH-000419	Myeloma	CCLE	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation substituting flanking lysine	0.1667
p.K949N	ACH-001541	Myeloma	CCLE	PPSTS	DEG_SPOP_SBC_1	959:963	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP10A

UniProt ID: O60312

Entrez ID: 57194

Protein name: Phospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP10A in