DegronMD

Uniprot ID: O60312

Source protein: Phospholipid-transporting ATPase VA

Source gene: ATP10A

Class: DEG_SPOP_SBC_1

Location: 959:963

E3 ligase: SPOP

DEGRON score: 0.8225

ASA_SCORE: 77.44

COIL: 0.8998

CONS_SCORE: 0.3779

DSS_SCORE: 0.5177

HELIX: 0.0568

FCONS_SCORE: 1.0579

RIG_SCORE: 0.6348

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S961T	TCGA-24-1436	OV	TCGA	PPSTS	DEG_SPOP_SBC_1	0.6005
p.S961T	DO32656	OV	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6005
p.R968H	TCGA-33-AASI	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	TCGA-BR-8591	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	TCGA-CN-6992	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	TCGA-DC-6681	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO234213	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO233254	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO14606	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO219129	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO36467	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.R968H	DO47973	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1944
p.P960H	TCGA-37-A5EL	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.6583
p.P960H	DO223718	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6583
p.S971N	TCGA-51-4081	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1111
p.S971N	DO26544	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.M952I	TCGA-55-8507	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1389
p.M952I	DO45412	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1389
p.P960T	TCGA-56-6546	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.5919
p.P960T	DO26542	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.5919
p.S971I	TCGA-A5-A0G1	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1111
p.S971I	DO42472	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.P959Q	TCGA-AG-A01W	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7035
p.P959Q	DO36382	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7035
p.V950L	TCGA-BK-A6W3	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0833
p.V950L	DO50076	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.V973M	TCGA-CM-4750	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0556
p.V973M	DO9298	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.V973M	SIDM01266	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.S956Y	TCGA-EY-A1G8	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.25
p.S956Y	DO43578	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.S961A	TCGA-L5-A4OW	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7588
p.S956C	TCGA-P5-A5EV	LGG	TCGA	PPSTS	DEG_SPOP_SBC_1	0.25
p.S956C	DO50160	LGG	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.S956F	SIDM02044	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.25
p.R969K	SIDM02022	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.T962M	SIDM00705	Non-Cancerous	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7423
p.T962M	SIDM00087	Plasma Cell Myeloma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7423
p.T962M	SIDM00706	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7423
p.T962M	SIDM00732	Glioblastoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7423
p.T962M	SIDM00720	Mesothelioma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7423
p.K949N	ACH-000419	Myeloma	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1667
p.K949N	ACH-001541	Myeloma	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with ATP10A mutations

All proteins holding degron of PPSTS