DegronMD - Q7Z7A4(PXK)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S494N	TCGA-BH-A0DE	BRCA	TCGA	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.0833
p.S494N	DO2688	BRCA	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.0833
p.P506L	TCGA-EE-A29X	SKCM	TCGA	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation altering degron motif	0.6471
p.P506L	TCGA-EE-A29X	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.6471
p.G495V	DO228948	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.1111
p.G495V	DO228948	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.S497I	DO229032	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.1667
p.S497I	DO229032	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1111
p.V510L	DO229037	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2778
p.V510L	DO229037	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.3056
p.A493S	DO229037	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.0556
p.T508A	DO23290	LINC	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation altering degron motif	0.7139
p.T508A	DO23290	LINC	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7139
p.S512P	DO219174	LUSC	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2222
p.S512P	DO219174	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.25
p.R499I	DO50075	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2222
p.R499I	DO50075	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499C	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2222
p.S499C	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499C	ACH-000611	Lymphoma	CCLE	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2222
p.S499C	ACH-000611	Lymphoma	CCLE	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499C	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation rewiring degron network	0.2222
p.S499C	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.P509S	KM12	large intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.6752
p.P506H	HCT-15	large intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	503:508	Mutation altering degron motif	0.6583
p.P506H	HCT-15	large intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.6583

Kaplan plot for PXK in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PXK

UniProt ID: Q7Z7A4

Entrez ID: 54899

Protein name: PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PXK in