DegronMD - Q8IXP5(C11orf53)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H171Q	TCGA-17-Z055	LUAD	TCGA	PPPY	ITCH	179:182	Mutation rewiring degron network	0.1111
p.L136I	TCGA-78-8662	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.L136I	DO45346	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.P174L	TCGA-AA-3982	COAD	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.0833
p.P174L	TCGA-AA-3982	COAD	TCGA	PPPY	ITCH	179:182	Mutation rewiring degron network	0.1944
p.P174L	DO8546	COAD	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.0833
p.P174L	DO8546	COAD	ICGC	PPPY	ITCH	179:182	Mutation rewiring degron network	0.1944
p.T128I	TCGA-AJ-A23O	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.T128I	TCGA-G4-6302	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.T128I	DO8778	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.T128I	DO43290	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.V121M	TCGA-AP-A059	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.V121M	DO41361	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.T189M	TCGA-B5-A11N	UCEC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7423
p.T189M	DO41458	UCEC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7423
p.T189M	SIDM00500	Colorectal Carcinoma	GDSC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7423
p.T189M	ACH-000959	Colon/Colorectal Cancer	CCLE	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7423
p.G66E	TCGA-BT-A2LB	BLCA	TCGA	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.3056
p.G66E	DO44098	BLCA	ICGC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.3056
p.G175R	TCGA-CN-6019	HNSC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1111
p.G175R	TCGA-CN-6019	HNSC	TCGA	PPPY	ITCH	179:182	Mutation rewiring degron network	0.2222
p.G175R	DO14316	HNSC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1111
p.G175R	DO14316	HNSC	ICGC	PPPY	ITCH	179:182	Mutation rewiring degron network	0.2222
p.P120T	TCGA-D7-A6EY	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0556
p.P120T	DO50118	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0556
p.V198E	TCGA-EE-A2GC	SKCM	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.0833
p.V198E	DO37839	SKCM	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.0833
p.P183S	TCGA-EE-A2M5	SKCM	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.6752
p.P183S	DO222423	MELA	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.6752
p.P183S	DO37425	SKCM	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.6752
p.G78S	TCGA-EE-A2MR	SKCM	TCGA	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.0833
p.G78S	DO37819	SKCM	ICGC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.0833
p.Y176C	TCGA-FI-A2D5	UCEC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1389
p.Y176C	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	179:182	Mutation rewiring degron network	0.25
p.Y176C	DO41331	UCEC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1389
p.Y176C	DO41331	UCEC	ICGC	PPPY	ITCH	179:182	Mutation rewiring degron network	0.25
p.P61L	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.1667
p.P61L	DO37406	SKCM	ICGC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.1667
p.D193V	TCGA-MA-AA42	CESC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.2222
p.D193V	DO219724	CESC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.2222
p.S134R	TCGA-MH-A560	KIRP	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7427
p.S134R	DO48474	KIRP	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7427
p.T133M	TCGA-XK-AAIW	PRAD	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7423
p.T133M	DO51407	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7423
p.T133M	SIDM00090	Ovarian Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7423
p.E63D	DO229009	LICA	ICGC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.2222
p.P196S	DO50970	LICA	ICGC	PFTPFMT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1389
p.P179L	DO231534	LINC	ICGC	PPPY	ITCH	179:182	Mutation altering degron motif	0.7582
p.H172R	DO232761	PBCA	ICGC	PPPY	ITCH	179:182	Mutation rewiring degron network	0.1389
p.E140K	SIDM01048	Plasma Cell Myeloma	GDSC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.E140K	ACH-000821	Myeloma	CCLE	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.D169Y	SIDM00472	Ovarian Carcinoma	GDSC	PPPY	ITCH	179:182	Mutation rewiring degron network	0.0556
p.D169Y	ACH-001630	Ovarian Cancer	CCLE	PPPY	ITCH	179:182	Mutation rewiring degron network	0.0556
p.Y65H	SIDM00530	Esophageal Carcinoma	GDSC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.2778
p.Y65H	ACH-001544	Esophageal Cancer	CCLE	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.2778
p.G78C	SIDM00118	Colorectal Carcinoma	GDSC	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.0833
p.G78C	ACH-001081	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	67:69	Mutation rewiring degron network	0.0833
p.D124Y	SIDM01608	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.D124Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C11orf53

UniProt ID: Q8IXP5

Entrez ID: 341032

Protein name: Uncharacterized protein C11orf53

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C11orf53 in