DegronMD

Uniprot ID: Q8IXP5

Source protein: Uncharacterized protein C11orf53

Source gene: C11orf53

Class: DEG_SCF_FBW7_1

Location: 183:189

E3 ligase: FBXW7

DEGRON score: 0.9036

ASA_SCORE: 65.8143

COIL: 0.767

CONS_SCORE: 0.6603

DSS_SCORE: 0.514

HELIX: 0.0331

FCONS_SCORE: 0.9819

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P174L	TCGA-AA-3982	COAD	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.0833
p.P174L	DO8546	COAD	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.0833
p.T189M	TCGA-B5-A11N	UCEC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.7423
p.T189M	DO41458	UCEC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.7423
p.T189M	SIDM00500	Colorectal Carcinoma	GDSC	PFTPFMT	DEG_SCF_FBW7_1	0.7423
p.T189M	ACH-000959	Colon/Colorectal Cancer	CCLE	PFTPFMT	DEG_SCF_FBW7_1	0.7423
p.G175R	TCGA-CN-6019	HNSC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.1111
p.G175R	DO14316	HNSC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.1111
p.V198E	TCGA-EE-A2GC	SKCM	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.0833
p.V198E	DO37839	SKCM	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.0833
p.P183S	TCGA-EE-A2M5	SKCM	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.6752
p.P183S	DO222423	MELA	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.6752
p.P183S	DO37425	SKCM	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.6752
p.Y176C	TCGA-FI-A2D5	UCEC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.1389
p.Y176C	DO41331	UCEC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.1389
p.D193V	TCGA-MA-AA42	CESC	TCGA	PFTPFMT	DEG_SCF_FBW7_1	0.2222
p.D193V	DO219724	CESC	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.2222
p.P196S	DO50970	LICA	ICGC	PFTPFMT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXP5	Uncharacterized protein C11orf53	DEG_SCF_FBW7_1	183:189	PFTPFMT	FBXW7	0.9036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons