DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SPOP_SBC_1

Location: 483:487

E3 ligase: SPOP

DEGRON score: 0.9614

ASA_SCORE: 74.54

COIL: 0.934

CONS_SCORE: 0.6566

DSS_SCORE: 0.7427

HELIX: 0.0486

FCONS_SCORE: 0.9511

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P473L	TCGA-AA-3510	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0556
p.P473L	DO7783	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.P493S	TCGA-B5-A3FA	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1667
p.P493S	DO52402	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.P476S	TCGA-R6-A6XG	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1389
p.P495T	DO6994	CLLE	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.T474K	DO222549	ESCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.T481N	DO233823	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.T474A	DO50737	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q488H	DO23132	LINC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.Q488H	ACH-000975	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.3056
p.P483L	DO228708	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7582
p.T481S	SIDM00614	Hepatocellular Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.T481S	ACH-000848	Liver Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.2778
p.T481S	JHH-7	liver	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A489T	SIDM00282	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A489T	ACH-000998	Colon/Colorectal Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A489T	CW-2	large_intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with POM121L2 mutations

All proteins holding degron of PPSTS