DegronMD - Q96KW2(POM121L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A629G	TCGA-17-Z033	LUAD	TCGA	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2778
p.S798F	TCGA-A5-A2K5	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798F	TCGA-E6-A1LX	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798F	DO41020	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798F	DO41379	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.D634Y	TCGA-A5-A2K5	UCEC	TCGA	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.D634Y	DO41379	UCEC	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.S798C	TCGA-A8-A097	BRCA	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798C	DO6240	BRCA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.P473L	TCGA-AA-3510	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0556
p.P473L	DO7783	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0556
p.S635Y	TCGA-AA-A010	COAD	TCGA	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.S134Y	TCGA-AJ-A5DW	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.712
p.S134Y	DO50075	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.712
p.A140T	TCGA-AX-A1C9	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.A140T	DO43098	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.P755T	TCGA-AX-A2HC	UCEC	TCGA	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.P755T	TCGA-AX-A2HC	UCEC	TCGA	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.2778
p.P755T	DO41572	UCEC	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.P755T	DO41572	UCEC	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.2778
p.A805V	TCGA-B5-A1MX	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.25
p.A805V	DO41999	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.25
p.P493S	TCGA-B5-A3FA	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.P493S	DO52402	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.P763H	TCGA-BS-A0V7	UCEC	TCGA	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0556
p.P763H	DO42392	UCEC	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0556
p.S798Y	TCGA-CA-6718	COAD	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798Y	TCGA-EO-A3AV	UCEC	TCGA	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798Y	DO7801	COAD	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798Y	DO222762	COCA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798Y	DO220858	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.S798Y	DO52412	UCEC	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.P476S	TCGA-R6-A6XG	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1389
p.T626N	TCGA-RG-A7D4	LIHC	TCGA	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.7055
p.T626N	DO52316	LIHC	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.7055
p.L728V	DO218669	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.L706V	DO225347	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.M624I	DO222817	BTCA	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.6507
p.P495T	DO6994	CLLE	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1111
p.P762L	DO229016	COCA	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0833
p.P762L	DO229003	COCA	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0833
p.P762L	DO231091	LUSC	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0833
p.L748M	DO234389	ESAD	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation altering degron motif	0.5999
p.T474K	DO222549	ESCA	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.S621F	DO233098	GACA	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2778
p.T481N	DO233823	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.S744C	DO233834	GACA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.643
p.A730T	DO14232	HNSC	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.P125A	DO228245	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1944
p.G143A	DO228856	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.T474A	DO50737	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.W738L	DO50931	LICA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.3056
p.W738L	DO50931	LICA	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.0556
p.Q488H	DO23132	LINC	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.3056
p.Q488H	ACH-000975	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.3056
p.T620N	DO23344	LINC	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.25
p.L728M	DO224563	LUSC	ICGC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.T810A	DO220880	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation altering degron motif	0.7139
p.T810A	DO222702	MELA	ICGC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation altering degron motif	0.7139
p.P755L	DO220889	MELA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.P755L	DO220889	MELA	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.2778
p.P755L	DO222595	MELA	ICGC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.P755L	DO222595	MELA	ICGC	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation rewiring degron network	0.2778
p.P727S	DO220886	MELA	ICGC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0833
p.E136K	DO222396	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.G615N	DO222632	MELA	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.V138E	DO222749	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2222
p.G615D	DO232761	PBCA	ICGC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.P483L	DO228708	PRAD	ICGC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7582
p.A827P	DO46992	RECA	ICGC	LTPSAS	DEG_SCF_FBW7_1	831:836	Mutation rewiring degron network	0.2222
p.G723S	DO37659	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1944
p.V622L	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.V622L	ACH-000521	Lung Cancer	CCLE	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.V622L	NCI-H2030	lung	COSMIC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.T481S	SIDM00614	Hepatocellular Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.T481S	ACH-000848	Liver Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.T481S	JHH-7	liver	COSMIC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.S713F	SIDM01175	Other Sarcomas	GDSC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.3056
p.S713F	ACH-002309	Sarcoma	CCLE	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.3056
p.S713F	SW684	soft tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.3056
p.F613L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.F613L	ACH-000733	Lung Cancer	CCLE	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.F613L	NCI-H1838	lung	COSMIC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.T824A	SIDM00650	Small Cell Lung Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.T824A	SIDM00650	Small Cell Lung Carcinoma	GDSC	LTPSAS	DEG_SCF_FBW7_1	831:836	Mutation rewiring degron network	0.1389
p.T824A	SIDM01681	Non-Cancerous	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.T824A	SIDM01681	Non-Cancerous	GDSC	LTPSAS	DEG_SCF_FBW7_1	831:836	Mutation rewiring degron network	0.1389
p.T824A	SIDM00785	Acute Myeloid Leukemia	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.0556
p.T824A	SIDM00785	Acute Myeloid Leukemia	GDSC	LTPSAS	DEG_SCF_FBW7_1	831:836	Mutation rewiring degron network	0.1389
p.V617L	SIDM01039	Other Solid Cancers	GDSC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1667
p.V617L	JAR	placenta	COSMIC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1667
p.A816V	SIDM00282	Colorectal Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.2778
p.A816V	SIDM00878	Breast Carcinoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation rewiring degron network	0.2778
p.A489T	SIDM00282	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.A489T	ACH-000998	Colon/Colorectal Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.A489T	CW-2	large intestine	COSMIC	PPSTS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.S726I	SIDM00422	Hodgkin's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.S726I	ACH-001203	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.S726I	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.V623I	SIDM00422	Hodgkin's Lymphoma	GDSC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.7076
p.V623I	ACH-001203	Lymphoma	CCLE	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.7076
p.V623I	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VMSTT	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.7076
p.V129L	SIDM00793	Burkitt's Lymphoma	GDSC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.3056
p.V129L	ACH-002236	Lymphoma	CCLE	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.3056
p.V129L	EB-3	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.3056
p.N737I	SIDM00999	Bladder Carcinoma	GDSC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.N737I	639-V	urinary tract	COSMIC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.T742A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7139
p.T742A	ACH-001127	Leukemia	CCLE	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7139
p.T742A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LASTPSIS	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7139
p.P809S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation altering degron motif	0.5641
p.P809S	ACH-001638	Lymphoma	CCLE	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation altering degron motif	0.5641
p.P809S	RC-K8	haematopoietic and lymphoid tissue	COSMIC	LPTPMPT	DEG_SCF_FBW7_1	808:814	Mutation altering degron motif	0.5641
p.G143V	SIDM00867	Glioblastoma	GDSC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.G143V	ACH-000863	Brain Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.G143V	DBTRG-05MG	central nervous system	COSMIC	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.I712L	SIDM00839	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.2778
p.I712L	ACH-000950	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.2778
p.I712L	LoVo	large intestine	COSMIC	PRSST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.2778
p.T753K	ACH-000979	Prostate Cancer	CCLE	LTPAIT	DEG_SCF_FBW7_1	748:753	Mutation altering degron motif	0.7306
p.T844I	ACH-001413	Bladder Cancer	CCLE	LTPSAS	DEG_SCF_FBW7_1	831:836	Mutation rewiring degron network	0.1111
p.D126V	ACH-001664	Gastric Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POM121L2

UniProt ID: Q96KW2

Entrez ID: 94026

Protein name: POM121-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POM121L2 in