DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SCF_FBW7_1

Location: 748:753

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 77.05

COIL: 0.9378

CONS_SCORE: 0.4813

DSS_SCORE: 0.4849

HELIX: 0.018

FCONS_SCORE: 0.7608

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P755T	TCGA-AX-A2HC	UCEC	TCGA	LTPAIT	DEG_SCF_FBW7_1	0.2778
p.P755T	DO41572	UCEC	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.2778
p.P763H	TCGA-BS-A0V7	UCEC	TCGA	LTPAIT	DEG_SCF_FBW7_1	0.0556
p.P763H	DO42392	UCEC	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.0556
p.P762L	DO229016	COCA	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.0833
p.P762L	DO229003	COCA	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.0833
p.P762L	DO231091	LUSC	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.0833
p.L748M	DO234389	ESAD	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.5999
p.W738L	DO50931	LICA	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.0556
p.P755L	DO220889	MELA	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.2778
p.P755L	DO222595	MELA	ICGC	LTPAIT	DEG_SCF_FBW7_1	0.2778
p.T753K	ACH-000979	Prostate Cancer	CCLE	LTPAIT	DEG_SCF_FBW7_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KW2	POM121-like protein 2	DEG_SCF_FBW7_1	748:753	LTPAIT	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons