DegronMD

Uniprot ID: Q96KW2

Source protein: POM121-like protein 2

Source gene: POM121L2

Class: DEG_SPOP_SBC_1

Location: 714:718

E3 ligase: SPOP

DEGRON score: 0.764

ASA_SCORE: 89.14

COIL: 0.9102

CONS_SCORE: 0.6406

DSS_SCORE: 0.3554

HELIX: 0.0442

FCONS_SCORE: 1.0098

RIG_SCORE: 0.731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L728V	DO218669	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.L706V	DO225347	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1111
p.L728M	DO224563	LUSC	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.P727S	DO220886	MELA	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.G723S	DO37659	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.S713F	SIDM01175	Other Sarcomas	GDSC	PRSST	DEG_SPOP_SBC_1	0.3056
p.S713F	ACH-002309	Sarcoma	CCLE	PRSST	DEG_SPOP_SBC_1	0.3056
p.S713F	SW684	soft_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.3056
p.S726I	SIDM00422	Hodgkin's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.1111
p.S726I	ACH-001203	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	0.1111
p.S726I	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.1111
p.I712L	SIDM00839	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.2778
p.I712L	ACH-000950	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.2778
p.I712L	LoVo	large_intestine	COSMIC	PRSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons