DegronMD

Uniprot ID: Q8TD19

Source protein: Serine/threonine-protein kinase Nek9

Source gene: NEK9

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.8086

ASA_SCORE: 102.24

COIL: 0.948

CONS_SCORE: 0.402

DSS_SCORE: 0.5015

HELIX: 0.037

FCONS_SCORE: 1.0297

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R328I	TCGA-52-7622	LUSC	TCGA	PRSST	DEG_SPOP_SBC_1	0.3056
p.R328I	DO26764	LUSC	ICGC	PRSST	DEG_SPOP_SBC_1	0.3056
p.E336Q	TCGA-A2-A3Y0	BRCA	TCGA	PRSST	DEG_SPOP_SBC_1	0.25
p.E336Q	DO44273	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.25
p.A340D	TCGA-A5-A0G2	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.1389
p.A340D	DO41235	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.1389
p.S332G	TCGA-CQ-7063	HNSC	TCGA	PRSST	DEG_SPOP_SBC_1	0.8104
p.S332G	DO14702	HNSC	ICGC	PRSST	DEG_SPOP_SBC_1	0.8104
p.A337E	TCGA-XU-A92T	THYM	TCGA	PRSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons