DegronMD

Uniprot ID: O94929

Source protein: Actin-binding LIM protein 3

Source gene: ABLIM3

Class: DEG_SPOP_SBC_1

Location: 545:549

E3 ligase: SPOP

DEGRON score: 0.9681

ASA_SCORE: 82.78

COIL: 0.8948

CONS_SCORE: 0.6267

DSS_SCORE: 0.5676

HELIX: 0.0724

FCONS_SCORE: 1.3193

RIG_SCORE: 0.6043

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S548F	TCGA-FW-A3R5	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	0.7982
p.S548F	DO37406	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.7982
p.S547R	TCGA-24-2290	OV	TCGA	PRSST	DEG_SPOP_SBC_1	0.7427
p.S547R	DO30090	OV	ICGC	PRSST	DEG_SPOP_SBC_1	0.7427
p.R546Q	TCGA-HU-A4H5	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.6218
p.R546Q	TCGA-ZB-A966	THYM	TCGA	PRSST	DEG_SPOP_SBC_1	0.6218
p.R546Q	DO222454	BTCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R546Q	DO50384	ESAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R546Q	DO47727	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R546Q	SIDM01301	Esophageal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R552W	TCGA-DU-6392	LGG	TCGA	PRSST	DEG_SPOP_SBC_1	0.25
p.E553K	SIDM00963	Breast Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.2222
p.E553K	ACH-000927	Breast Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.2222
p.E553K	BT-474	breast	COSMIC	PRSST	DEG_SPOP_SBC_1	0.2222
p.L540M	LXF-289	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	0.1944
p.N539S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.1667
p.H556L	TCGA-D5-6532	COAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.1389
p.R557Q	K2	skin	COSMIC	PRSST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...

Showing 1 to 17 of 17 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons