DegronMD - A0JNW5(UHRF1BP1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E888K	TCGA-66-2773	LUSC	TCGA	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.7022
p.A1338T	TCGA-AX-A0J1	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1667
p.R1329Q	TCGA-BS-A0UV	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	ACH-000729	Lung Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	ACH-002275	Leukemia	CCLE	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	NCI-H1963	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.R1329Q	MN-60	haematopoietic and lymphoid tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6218
p.P1337S	TCGA-D1-A167	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1944
p.P1339T	TCGA-D3-A2JP	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1389
p.D1326N	TCGA-DS-A0VK	CESC	TCGA	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.2778
p.S907P	TCGA-XF-A9T3	BLCA	TCGA	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.0556
p.R887H	DO2479	BRCA	ICGC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.8244
p.N886K	DO233035	GACA	ICGC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.3056
p.R887C	DO232761	PBCA	ICGC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.8301
p.R887C	HCC2998	large intestine	COSMIC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.8301
p.S891F	DO37839	SKCM	ICGC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.9093
p.L882F	SIDM00960	Colorectal Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1944
p.L882F	ACH-000798	Colon/Colorectal Cancer	CCLE	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1944
p.L882F	CL-40	large intestine	COSMIC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1944
p.E1336Q	SIDM01021	Glioblastoma	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.2222
p.E1336Q	ACH-002223	Brain Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.2222
p.E1336Q	D-245MG	central nervous system	COSMIC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.2222
p.F905I	SIDM00846	Cervical Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.F905I	SIDM00493	Other Solid Cancers	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.F905I	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.F905I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.F905I	SIDM01173	Rhabdomyosarcoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.F905I	SIDM00628	Breast Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1111
p.R1329G	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6457
p.R1329G	ACH-000980	Lung Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6457
p.R1329G	NCI-H1155	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6457
p.P1328S	SIDM00493	Other Solid Cancers	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6752
p.P1328S	SIDM01173	Rhabdomyosarcoma	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation altering degron motif	0.6752
p.G903W	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1667
p.G903W	ACH-000852	Lung Cancer	CCLE	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1667
p.G903W	NCI-H1435	lung	COSMIC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.1667
p.N1322H	SIDM01588	Endometrial Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1667
p.N1322H	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	1328:1332	Mutation rewiring degron network	0.1667
p.S901P	IPC-298	skin	COSMIC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation rewiring degron network	0.2222
p.Q893P	OVCAR-4	ovary	COSMIC	SESVSPVVPDY	DEG_COP1_1	887:897	Mutation altering degron motif	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UHRF1BP1L

UniProt ID: A0JNW5

Entrez ID: 23074

Protein name: UHRF1-binding protein 1-like (Syntaxin-6 Habc-interacting protein of 164 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UHRF1BP1L in