DegronMD

Uniprot ID: A0JNW5

Source protein: UHRF1-binding protein 1-like

Source gene: UHRF1BP1L

Class: DEG_COP1_1

Location: 887:897

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 80.4455

COIL: 0.8422

CONS_SCORE: 0.3603

DSS_SCORE: 0.4041

HELIX: 0.1049

FCONS_SCORE: 1.2415

RIG_SCORE: 0.7105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E888K	TCGA-66-2773	LUSC	TCGA	SESVSPVVPDY	DEG_COP1_1	0.7022
p.S907P	TCGA-XF-A9T3	BLCA	TCGA	SESVSPVVPDY	DEG_COP1_1	0.0556
p.R887H	DO2479	BRCA	ICGC	SESVSPVVPDY	DEG_COP1_1	0.8244
p.N886K	DO233035	GACA	ICGC	SESVSPVVPDY	DEG_COP1_1	0.3056
p.R887C	DO232761	PBCA	ICGC	SESVSPVVPDY	DEG_COP1_1	0.8301
p.R887C	HCC2998	large_intestine	COSMIC	SESVSPVVPDY	DEG_COP1_1	0.8301
p.S891F	DO37839	SKCM	ICGC	SESVSPVVPDY	DEG_COP1_1	0.9093
p.L882F	SIDM00960	Colorectal Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1944
p.L882F	ACH-000798	Colon/Colorectal Cancer	CCLE	SESVSPVVPDY	DEG_COP1_1	0.1944
p.L882F	CL-40	large_intestine	COSMIC	SESVSPVVPDY	DEG_COP1_1	0.1944
p.F905I	SIDM00846	Cervical Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.F905I	SIDM00493	Other Solid Cancers	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.F905I	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.F905I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.F905I	SIDM01173	Rhabdomyosarcoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.F905I	SIDM00628	Breast Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1111
p.G903W	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SESVSPVVPDY	DEG_COP1_1	0.1667
p.G903W	ACH-000852	Lung Cancer	CCLE	SESVSPVVPDY	DEG_COP1_1	0.1667
p.G903W	NCI-H1435	lung	COSMIC	SESVSPVVPDY	DEG_COP1_1	0.1667
p.S901P	IPC-298	skin	COSMIC	SESVSPVVPDY	DEG_COP1_1	0.2222
p.Q893P	OVCAR-4	ovary	COSMIC	SESVSPVVPDY	DEG_COP1_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_COP1_1	887:897	SESVSPVVPDY	COP1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons