DegronMD - O00512(BCL9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M711R	TCGA-06-5856	GBM	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7521
p.M711R	DO13456	GBM	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7521
p.G575V	TCGA-55-1595	LUAD	TCGA	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1111
p.G575V	DO228948	LICA	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1111
p.G575V	DO23558	LUAD	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1111
p.P703H	TCGA-55-6979	LUAD	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.P703H	DO24110	LUAD	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.M716I	TCGA-AP-A1E0	UCEC	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.6507
p.M716I	DO43154	UCEC	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.6507
p.P576L	TCGA-B5-A11E	UCEC	TCGA	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1389
p.P576L	DO41644	UCEC	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1389
p.P699T	TCGA-BQ-7056	KIRP	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.1389
p.P699T	DO20872	KIRP	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.1389
p.P287H	TCGA-BR-8591	STAD	TCGA	PASST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1944
p.P287H	DO47973	STAD	ICGC	PASST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1944
p.S288F	TCGA-CN-A640	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	292:296	Mutation blocking phosphorylation signal	0.6667
p.S288F	DO52046	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	292:296	Mutation blocking phosphorylation signal	0.6667
p.P145Q	TCGA-D3-A1Q4	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.P145Q	DO47631	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.D719Y	TCGA-D3-A3CE	SKCM	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.D719Y	DO37405	SKCM	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.N723T	TCGA-D9-A4Z6	SKCM	TCGA	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.1389
p.N723T	DO47485	SKCM	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.1389
p.P156S	TCGA-DF-A2KU	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.P156S	DO223286	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.R508W	TCGA-DK-A3WW	BLCA	TCGA	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R508W	DO481	BLCA	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R508W	DO222843	MELA	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R508W	ACH-001377	Pancreatic Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.G509E	TCGA-EY-A1GU	UCEC	TCGA	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1667
p.G509E	DO41518	UCEC	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1667
p.A150S	TCGA-F4-6703	COAD	TCGA	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.A150S	DO9908	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.G586D	DO223387	CLLE	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.6087
p.A527V	DO227984	COCA	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0833
p.R705Q	DO50349	ESAD	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.3056
p.G586C	DO229019	LICA	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.6489
p.G715W	DO229028	LICA	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7825
p.I599L	DO23248	LINC	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1111
p.P292S	DO222409	MELA	ICGC	PASST	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.6752
p.H158Y	DO232045	ORCA	ICGC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25
p.M716V	DO229459	SKCA	ICGC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.6097
p.R705W	SIDM01314	Colorectal Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.3056
p.G302D	SIDM00107	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.S591N	SIDM00506	Small Cell Lung Carcinoma	GDSC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.5958
p.S591N	ACH-000508	Lung Cancer	CCLE	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.5958
p.S591N	COR-L88	lung	COSMIC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.5958
p.G696A	SIDM00928	Breast Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.0556
p.G696A	CAL-85-1	breast	COSMIC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation rewiring degron network	0.0556
p.P600Q	SIDM00182	Head and Neck Carcinoma	GDSC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.P600Q	LB771-HNC	upper aerodigestive tract	COSMIC	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.S714T	SIDM00044	Head and Neck Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7116
p.S714T	ACH-002295	Head and Neck Cancer	CCLE	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7116
p.S714T	PCI-30	upper aerodigestive tract	COSMIC	ELEFGMVPSGM	DEG_COP1_1	706:716	Mutation altering degron motif	0.7116
p.P514R	SIDM00566	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.P514R	ACH-001625	Head and Neck Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.P514R	OSC-19	upper aerodigestive tract	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.G159D	SIDM00500	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2222
p.G159D	ACH-000959	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2222
p.P305L	ACH-001061	Colon/Colorectal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.0833
p.S157A	ACH-001063	Ovarian Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	151:155	Mutation blocking phosphorylation signal	0.7222
p.S583C	ACH-002015	Eye Cancer	CCLE	SRPGLSGVS	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.643
p.H158Q	ACH-002235	Bladder Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25
p.H158Q	DSH1	urinary tract	COSMIC	PRSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL9

UniProt ID: O00512

Entrez ID: 607

Protein name: B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL9 in