DegronMD

Uniprot ID: O00512

Source protein: B-cell CLL/lymphoma 9 protein

Source gene: BCL9

Class: DEG_COP1_1

Location: 706:716

E3 ligase: COP1

DEGRON score: 0.9947

ASA_SCORE: 86.8455

COIL: 0.8465

CONS_SCORE: 0.72

DSS_SCORE: 0.562

HELIX: 0.12

FCONS_SCORE: 1.2639

RIG_SCORE: 0.6961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M711R	TCGA-06-5856	GBM	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.7521
p.M711R	DO13456	GBM	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.7521
p.P703H	TCGA-55-6979	LUAD	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.25
p.P703H	DO24110	LUAD	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.25
p.M716I	TCGA-AP-A1E0	UCEC	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.6507
p.M716I	DO43154	UCEC	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.6507
p.P699T	TCGA-BQ-7056	KIRP	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.1389
p.P699T	DO20872	KIRP	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.1389
p.D719Y	TCGA-D3-A3CE	SKCM	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.25
p.D719Y	DO37405	SKCM	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.25
p.N723T	TCGA-D9-A4Z6	SKCM	TCGA	ELEFGMVPSGM	DEG_COP1_1	0.1389
p.N723T	DO47485	SKCM	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.1389
p.R705Q	DO50349	ESAD	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.3056
p.G715W	DO229028	LICA	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.7825
p.M716V	DO229459	SKCA	ICGC	ELEFGMVPSGM	DEG_COP1_1	0.6097
p.R705W	SIDM01314	Colorectal Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	0.3056
p.G696A	SIDM00928	Breast Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	0.0556
p.G696A	CAL-85-1	breast	COSMIC	ELEFGMVPSGM	DEG_COP1_1	0.0556
p.S714T	SIDM00044	Head and Neck Carcinoma	GDSC	ELEFGMVPSGM	DEG_COP1_1	0.7116
p.S714T	ACH-002295	Head and Neck Cancer	CCLE	ELEFGMVPSGM	DEG_COP1_1	0.7116
p.S714T	PCI-30	upper_aerodigestive_tract	COSMIC	ELEFGMVPSGM	DEG_COP1_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00512	B-cell CLL/lymphoma 9 protein	DEG_COP1_1	706:716	ELEFGMVPSGM	COP1	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons