DegronMD

Uniprot ID: O00512

Source protein: B-cell CLL/lymphoma 9 protein

Source gene: BCL9

Class: DEG_APCC_DBOX_1

Location: 583:591

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9924

ASA_SCORE: 80.3333

COIL: 0.9559

CONS_SCORE: 0.7037

DSS_SCORE: 0.6107

HELIX: 0.017

FCONS_SCORE: 0.9098

RIG_SCORE: 0.5893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G575V	TCGA-55-1595	LUAD	TCGA	SRPGLSGVS	DEG_APCC_DBOX_1	0.1111
p.G575V	DO228948	LICA	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.1111
p.G575V	DO23558	LUAD	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.1111
p.P576L	TCGA-B5-A11E	UCEC	TCGA	SRPGLSGVS	DEG_APCC_DBOX_1	0.1389
p.P576L	DO41644	UCEC	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.1389
p.G586D	DO223387	CLLE	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.6087
p.G586C	DO229019	LICA	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.6489
p.I599L	DO23248	LINC	ICGC	SRPGLSGVS	DEG_APCC_DBOX_1	0.1111
p.S591N	SIDM00506	Small Cell Lung Carcinoma	GDSC	SRPGLSGVS	DEG_APCC_DBOX_1	0.5958
p.S591N	ACH-000508	Lung Cancer	CCLE	SRPGLSGVS	DEG_APCC_DBOX_1	0.5958
p.S591N	COR-L88	lung	COSMIC	SRPGLSGVS	DEG_APCC_DBOX_1	0.5958
p.P600Q	SIDM00182	Head and Neck Carcinoma	GDSC	SRPGLSGVS	DEG_APCC_DBOX_1	0.0833
p.P600Q	LB771-HNC	upper_aerodigestive_tract	COSMIC	SRPGLSGVS	DEG_APCC_DBOX_1	0.0833
p.S583C	ACH-002015	Eye Cancer	CCLE	SRPGLSGVS	DEG_APCC_DBOX_1	0.643

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00512	B-cell CLL/lymphoma 9 protein	DEG_APCC_DBOX_1	583:591	SRPGLSGVS	APC,CDC20,FZR1	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons