DegronMD - Q9Y5G5(PCDHGA8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R222C	TCGA-06-5416	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.719
p.R222C	DO10880	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.719
p.R227H	TCGA-38-4629	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227H	TCGA-86-A4JF	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227H	DO23771	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227H	DO45317	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227H	ACH-001197	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227C	TCGA-AX-A0J1	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.R227C	DO41199	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.V230M	TCGA-CG-4436	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.V230M	TCGA-DF-A2KZ	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.V230M	DO38320	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.V230M	DO52409	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.K219T	TCGA-VQ-A91S	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.K219T	DO222352	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.P898T	DO233115	GACA	ICGC	DYR	CBL_MET	890:892	Mutation rewiring degron network	0.1667
p.A214S	DO229028	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.V888M	DO25554	LUAD	ICGC	DYR	CBL_MET	890:892	Mutation rewiring degron network	0.2778
p.V888M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	890:892	Mutation rewiring degron network	0.2778
p.T213M	DO228428	MALY	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation blocking phosphorylation signal	0.5556
p.V895G	DO28089	OV	ICGC	DYR	CBL_MET	890:892	Mutation rewiring degron network	0.25
p.T884A	DO48918	PBCA	ICGC	DYR	CBL_MET	890:892	Mutation rewiring degron network	0.1667
p.A214T	DO219871	SKCA	ICGC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.A214T	SIDM00953	Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.A214T	CPC-N	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.R892H	DO41871	UCEC	ICGC	DYR	CBL_MET	890:892	Mutation altering degron motif	0.8244
p.R892C	DO42568	UCEC	ICGC	DYR	CBL_MET	890:892	Mutation altering degron motif	0.8301
p.P221R	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.7512
p.P221R	SIDM00736	Non-Cancerous	GDSC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.7512
p.G218S	SIDM00243	Other Solid Cancers	GDSC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.G218S	SIDM01659	Kidney Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.G218S	ACH-000313	Kidney Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.G218S	ACH-002288	Embryonal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.G218S	NEC8	testis	COSMIC	PRSST	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.S223C	ACH-002471	Primary	CCLE	PRSST	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGA8

UniProt ID: Q9Y5G5

Entrez ID: 9708

Protein name: Protocadherin gamma-A8 (PCDH-gamma-A8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGA8 in