DegronMD

Uniprot ID: Q9Y5G5

Source protein: Protocadherin gamma-A8

Source gene: PCDHGA8

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.8172

ASA_SCORE: 66.86

COIL: 0.42

CONS_SCORE: 0.5533

DSS_SCORE: 0.5036

HELIX: 0.0086

FCONS_SCORE: 0.751

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R222C	TCGA-06-5416	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	0.719
p.R222C	DO10880	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	0.719
p.R227H	TCGA-38-4629	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227H	TCGA-86-A4JF	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227H	DO23771	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227H	DO45317	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227H	ACH-001197	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227C	TCGA-AX-A0J1	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.2778
p.R227C	DO41199	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.V230M	TCGA-CG-4436	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.1944
p.V230M	TCGA-DF-A2KZ	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.1944
p.V230M	DO38320	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.V230M	DO52409	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.K219T	TCGA-VQ-A91S	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.2778
p.K219T	DO222352	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.A214S	DO229028	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1389
p.T213M	DO228428	MALY	ICGC	PRSST	DEG_SPOP_SBC_1	0.5556
p.A214T	DO219871	SKCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1389
p.A214T	SIDM00953	Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.1389
p.A214T	CPC-N	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	0.1389
p.P221R	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.7512
p.P221R	SIDM00736	Non-Cancerous	GDSC	PRSST	DEG_SPOP_SBC_1	0.7512
p.G218S	SIDM00243	Other Solid Cancers	GDSC	PRSST	DEG_SPOP_SBC_1	0.25
p.G218S	SIDM01659	Kidney Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.25
p.G218S	ACH-000313	Kidney Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.25
p.G218S	ACH-002288	Embryonal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.25
p.G218S	NEC8	testis	COSMIC	PRSST	DEG_SPOP_SBC_1	0.25
p.S223C	ACH-002471	Primary	CCLE	PRSST	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSST

Degron related mutations and impact score

Drug responses associated with PCDHGA8 mutations

All proteins holding degron of PRSST