DegronMD - O94929(ABLIM3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R524L	TCGA-22-1016	LUSC	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.R524L	DO26971	LUSC	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.S547R	TCGA-24-2290	OV	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.7427
p.S547R	TCGA-24-2290	OV	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7427
p.S547R	DO30090	OV	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.7427
p.S547R	DO30090	OV	ICGC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7427
p.P541L	TCGA-3N-A9WC	SKCM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6471
p.P541L	DO220891	MELA	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6471
p.P541L	DO51234	SKCM	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6471
p.G523V	TCGA-49-AARE	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0556
p.G523V	DO218922	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0556
p.M531I	TCGA-62-8399	LUAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.0556
p.M531I	TCGA-62-8399	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2778
p.R534W	TCGA-95-A4VN	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7523
p.R534W	DO51199	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7523
p.R534W	SIDM00654	Small Cell Lung Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7523
p.R534W	ACH-000866	Lung Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7523
p.R534W	NCI-H1048	lung	COSMIC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7523
p.P410T	TCGA-97-8176	LUAD	TCGA	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1389
p.P410T	DO218933	LUAD	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1389
p.R534Q	TCGA-AF-6655	READ	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.6218
p.R534Q	TCGA-AU-6004	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.6218
p.R534Q	DO7780	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.6218
p.R534Q	DO36895	READ	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.6218
p.R449W	TCGA-AP-A056	UCEC	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R449W	TCGA-AX-A2HD	UCEC	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R449W	TCGA-HT-A5RC	LGG	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R449W	DO48525	LGG	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R449W	DO42608	UCEC	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R449W	DO43971	UCEC	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.N439S	TCGA-B5-A0JY	UCEC	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1944
p.N439S	DO43041	UCEC	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1944
p.H556L	TCGA-D5-6532	COAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.0833
p.H556L	TCGA-D5-6532	COAD	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1389
p.R442Q	TCGA-DM-A1D7	COAD	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R442Q	DO10044	COAD	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R442Q	DO233893	GACA	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R442Q	SIDM00474	Ovarian Carcinoma	GDSC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R552W	TCGA-DU-6392	LGG	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.1944
p.R552W	TCGA-DU-6392	LGG	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.R407Q	TCGA-EE-A2M5	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.R407Q	DO222423	MELA	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.R407Q	DO37425	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.H450Y	TCGA-EO-A22R	UCEC	TCGA	PPIY	ITCH	444:447	Mutation rewiring degron network	0.25
p.S535L	TCGA-EO-A22R	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	DO42713	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	SIDM01037	Breast Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S548F	TCGA-FW-A3R5	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7982
p.S548F	DO37406	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.7982
p.S420C	TCGA-GS-A9TW	DLBC	TCGA	VRSST	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7541
p.S420C	DO219915	DLBC	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7541
p.R546Q	TCGA-HU-A4H5	STAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	TCGA-HU-A4H5	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.R546Q	TCGA-ZB-A966	THYM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	TCGA-ZB-A966	THYM	TCGA	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.R546Q	DO222454	BTCA	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	DO222454	BTCA	ICGC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.R546Q	DO50384	ESAD	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	DO50384	ESAD	ICGC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.R546Q	DO47727	STAD	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	DO47727	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.R546Q	SIDM01301	Esophageal Carcinoma	GDSC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6218
p.R546Q	SIDM01301	Esophageal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.6218
p.I526S	TCGA-IB-7651	PAAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1389
p.P410S	TCGA-IH-A3EA	SKCM	TCGA	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1389
p.P410S	DO37667	SKCM	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1389
p.R534L	TCGA-L9-A7SV	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7316
p.R534L	DO49875	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7316
p.P544S	TCGA-P3-A6T8	HNSC	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6752
p.P544S	DO49050	HNSC	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6752
p.P541S	TCGA-W3-A824	SKCM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6752
p.P541S	DO51271	SKCM	ICGC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.6752
p.R524Q	TCGA-ZB-A966	THYM	TCGA	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.R524Q	DO223048	ESCA	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.R524Q	DO219823	LGG	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.K527N	DO488	BLCA	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.R536W	DO2755	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.8634
p.H445L	DO7890	COAD	ICGC	PPIY	ITCH	444:447	Mutation altering degron motif	0.7313
p.D530Y	DO9828	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.Y411C	DO222503	COCA	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.6111
p.R407W	DO233767	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.S408L	DO233820	GACA	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.H412R	DO228909	LICA	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.M420I	DO24606	LUAD	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7618
p.G536E	DO222402	MELA	ICGC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7199
p.E442Q	DO35122	PACA	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.A443S	DO232663	PBCA	ICGC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.3056
p.H417Y	DO42713	UCEC	ICGC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7229
p.D437E	SIDM00845	Burkitt's Lymphoma	GDSC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1389
p.D437E	SIDM00224	Mesothelioma	GDSC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1389
p.D437E	ACH-000569	Lung Cancer	CCLE	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1389
p.D437E	IST-MES1	pleura	COSMIC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1389
p.E553K	SIDM00963	Breast Carcinoma	GDSC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.1667
p.E553K	SIDM00963	Breast Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2222
p.E553K	ACH-000927	Breast Cancer	CCLE	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.1667
p.E553K	ACH-000927	Breast Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2222
p.E553K	BT-474	breast	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.1667
p.E553K	BT-474	breast	COSMIC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.2222
p.R442W	SIDM01146	Gastric Carcinoma	GDSC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R442W	ACH-000932	Gastric Cancer	CCLE	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.R442W	NCI-SNU-1	stomach	COSMIC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.P445L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPIY	ITCH	444:447	Mutation altering degron motif	0.7582
p.P445L	ACH-000874	Leukemia	CCLE	PPIY	ITCH	444:447	Mutation altering degron motif	0.7582
p.P445L	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	444:447	Mutation altering degron motif	0.7582
p.L525Q	ACH-000872	Lung Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1111
p.S419A	ACH-001991	Primary	CCLE	VRSST	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7588
p.R439W	NCI-H1048	lung	COSMIC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.1944
p.N523S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0556
p.E442K	BT-474	breast	COSMIC	PPIY	ITCH	444:447	Mutation rewiring degron network	0.2778
p.S543R	IMR-5	autonomic ganglia	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation altering degron motif	0.7427
p.P412L	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.R409W	NCI-SNU-1	stomach	COSMIC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation blocking phosphorylation signal	0.5556
p.R423W	NCI-H1048	lung	COSMIC	VRSST	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2778
p.L540M	LXF-289	lung	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.3056
p.L540M	LXF-289	lung	COSMIC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.L540M	LXF-289	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1944
p.R557Q	K2	skin	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.0556
p.R557Q	K2	skin	COSMIC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.N539S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	541:547	Mutation rewiring degron network	0.2778
p.N539S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2778
p.N539S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABLIM3

UniProt ID: O94929

Entrez ID: 22885

Protein name: Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABLIM3 in