DegronMD

Uniprot ID: O94929

Source protein: Actin-binding LIM protein 3

Source gene: ABLIM3

Class: DEG_SCF_FBW7_1

Location: 541:547

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 84.5857

COIL: 0.9326

CONS_SCORE: 0.5921

DSS_SCORE: 0.5737

HELIX: 0.0311

FCONS_SCORE: 1.3069

RIG_SCORE: 0.631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S547R	TCGA-24-2290	OV	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.7427
p.S547R	DO30090	OV	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.7427
p.P541L	TCGA-3N-A9WC	SKCM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.6471
p.P541L	DO220891	MELA	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6471
p.P541L	DO51234	SKCM	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6471
p.M531I	TCGA-62-8399	LUAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.0556
p.H556L	TCGA-D5-6532	COAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.0833
p.R552W	TCGA-DU-6392	LGG	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.1944
p.R546Q	TCGA-HU-A4H5	STAD	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.R546Q	TCGA-ZB-A966	THYM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.R546Q	DO222454	BTCA	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.R546Q	DO50384	ESAD	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.R546Q	DO47727	STAD	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.R546Q	SIDM01301	Esophageal Carcinoma	GDSC	PWTPPRS	DEG_SCF_FBW7_1	0.6218
p.P544S	TCGA-P3-A6T8	HNSC	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.6752
p.P544S	DO49050	HNSC	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6752
p.P541S	TCGA-W3-A824	SKCM	TCGA	PWTPPRS	DEG_SCF_FBW7_1	0.6752
p.P541S	DO51271	SKCM	ICGC	PWTPPRS	DEG_SCF_FBW7_1	0.6752
p.E553K	SIDM00963	Breast Carcinoma	GDSC	PWTPPRS	DEG_SCF_FBW7_1	0.1667
p.E553K	ACH-000927	Breast Cancer	CCLE	PWTPPRS	DEG_SCF_FBW7_1	0.1667
p.E553K	BT-474	breast	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	0.1667
p.S543R	IMR-5	autonomic_ganglia	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	0.7427
p.L540M	LXF-289	lung	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	0.3056
p.R557Q	K2	skin	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	0.0556
p.N539S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PWTPPRS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94929	Actin-binding LIM protein 3	DEG_SCF_FBW7_1	541:547	PWTPPRS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons