DegronMD

Uniprot ID: O94929

Source protein: Actin-binding LIM protein 3

Source gene: ABLIM3

Class: ITCH

Location: 444:447

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9628

ASA_SCORE: 71.25

COIL: 0.8725

CONS_SCORE: 0.4298

DSS_SCORE: 0.5417

HELIX: 0.0768

FCONS_SCORE: 1.1233

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R449W	TCGA-AP-A056	UCEC	TCGA	PPIY	ITCH	0.2778
p.R449W	TCGA-AX-A2HD	UCEC	TCGA	PPIY	ITCH	0.2778
p.R449W	TCGA-HT-A5RC	LGG	TCGA	PPIY	ITCH	0.2778
p.R449W	DO48525	LGG	ICGC	PPIY	ITCH	0.2778
p.R449W	DO42608	UCEC	ICGC	PPIY	ITCH	0.2778
p.R449W	DO43971	UCEC	ICGC	PPIY	ITCH	0.2778
p.N439S	TCGA-B5-A0JY	UCEC	TCGA	PPIY	ITCH	0.1944
p.N439S	DO43041	UCEC	ICGC	PPIY	ITCH	0.1944
p.R442Q	TCGA-DM-A1D7	COAD	TCGA	PPIY	ITCH	0.2778
p.R442Q	DO10044	COAD	ICGC	PPIY	ITCH	0.2778
p.R442Q	DO233893	GACA	ICGC	PPIY	ITCH	0.2778
p.R442Q	SIDM00474	Ovarian Carcinoma	GDSC	PPIY	ITCH	0.2778
p.H450Y	TCGA-EO-A22R	UCEC	TCGA	PPIY	ITCH	0.25
p.H445L	DO7890	COAD	ICGC	PPIY	ITCH	0.7313
p.E442Q	DO35122	PACA	ICGC	PPIY	ITCH	0.2778
p.A443S	DO232663	PBCA	ICGC	PPIY	ITCH	0.3056
p.D437E	SIDM00845	Burkitt's Lymphoma	GDSC	PPIY	ITCH	0.1389
p.D437E	SIDM00224	Mesothelioma	GDSC	PPIY	ITCH	0.1389
p.D437E	ACH-000569	Lung Cancer	CCLE	PPIY	ITCH	0.1389
p.D437E	IST-MES1	pleura	COSMIC	PPIY	ITCH	0.1389
p.R442W	SIDM01146	Gastric Carcinoma	GDSC	PPIY	ITCH	0.2778
p.R442W	ACH-000932	Gastric Cancer	CCLE	PPIY	ITCH	0.2778
p.R442W	NCI-SNU-1	stomach	COSMIC	PPIY	ITCH	0.2778
p.P445L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPIY	ITCH	0.7582
p.P445L	ACH-000874	Leukemia	CCLE	PPIY	ITCH	0.7582
p.P445L	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPIY	ITCH	0.7582
p.R439W	NCI-H1048	lung	COSMIC	PPIY	ITCH	0.1944
p.E442K	BT-474	breast	COSMIC	PPIY	ITCH	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons