DegronMD

Uniprot ID: O43281

Source protein: Embryonal Fyn-associated substrate

Source gene: EFS

Class: ITCH

Location: 214:217

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6414

ASA_SCORE: 85.475

COIL: 0.8143

CONS_SCORE: 0.5837

DSS_SCORE: 0.518

HELIX: 0.0178

FCONS_SCORE: 0.9719

RIG_SCORE: 0.6734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A226V	TCGA-36-2534	OV	TCGA	PPIY	ITCH	0.0833
p.A226V	TCGA-AX-A0J1	UCEC	TCGA	PPIY	ITCH	0.0833
p.A226V	DO23408	LINC	ICGC	PPIY	ITCH	0.0833
p.A226V	DO29046	OV	ICGC	PPIY	ITCH	0.0833
p.A226V	DO41199	UCEC	ICGC	PPIY	ITCH	0.0833
p.P215T	TCGA-BR-8361	STAD	TCGA	PPIY	ITCH	0.7031
p.P215T	DO48032	STAD	ICGC	PPIY	ITCH	0.7031
p.E211K	TCGA-BT-A42C	BLCA	TCGA	PPIY	ITCH	0.25
p.E211K	TCGA-IQ-A61E	HNSC	TCGA	PPIY	ITCH	0.25
p.E211K	DO49725	BLCA	ICGC	PPIY	ITCH	0.25
p.E211K	DO223002	ESCA	ICGC	PPIY	ITCH	0.25
p.E211K	DO44429	HNSC	ICGC	PPIY	ITCH	0.25
p.I216M	TCGA-IQ-A61E	HNSC	TCGA	PPIY	ITCH	0.6507
p.I216M	DO44429	HNSC	ICGC	PPIY	ITCH	0.6507
p.R225L	TCGA-KQ-A41N	BLCA	TCGA	PPIY	ITCH	0.1111
p.R225L	DO223588	BLCA	ICGC	PPIY	ITCH	0.1111
p.A219D	DO229027	LICA	ICGC	PPIY	ITCH	0.2778
p.P212T	DO229031	LICA	ICGC	PPIY	ITCH	0.2778
p.P214H	SIDM00863	Burkitt's Lymphoma	GDSC	PPIY	ITCH	0.7694
p.P214H	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PPIY	ITCH	0.7694
p.E207K	SIDM00679	Cervical Carcinoma	GDSC	PPIY	ITCH	0.1389
p.E207K	ACH-001525	Cervical Cancer	CCLE	PPIY	ITCH	0.1389
p.E207K	HT-3	cervix	COSMIC	PPIY	ITCH	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons