DegronMD - Q9Y2H6(FNDC3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R736C	TCGA-5M-AAT6	COAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	TCGA-AP-A1DV	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	TCGA-AX-A2HC	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	DO223703	COAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	DO232224	PBCA	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	DO43186	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	DO41572	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.R736C	ACH-001736	Leukemia	CCLE	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.L311M	TCGA-B5-A1MR	UCEC	TCGA	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.1667
p.L311M	DO41758	UCEC	ICGC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.1667
p.E748K	TCGA-BR-8372	STAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation altering degron motif	0.7022
p.E748K	DO47873	STAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation altering degron motif	0.7022
p.L735R	TCGA-D1-A1NZ	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1111
p.L735R	DO41536	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1111
p.P303Q	TCGA-D3-A2JP	SKCM	TCGA	ETDESSVPEL	DEG_COP1_1	296:305	Mutation altering degron motif	0.7035
p.P303Q	DO47407	SKCM	ICGC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation altering degron motif	0.7035
p.N739D	TCGA-DI-A1BU	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.2222
p.N739D	DO42023	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.2222
p.P79S	TCGA-EE-A29E	SKCM	TCGA	PPGY	ITCH	78:81	Mutation altering degron motif	0.6752
p.P79S	DO37831	SKCM	ICGC	PPGY	ITCH	78:81	Mutation altering degron motif	0.6752
p.D751V	TCGA-KL-8341	KICH	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.25
p.D751V	DO220349	KICH	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.25
p.G757V	TCGA-MP-A4T7	LUAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.0833
p.G757V	DO45370	LUAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.0833
p.V77L	TCGA-W5-AA34	CHOL	TCGA	PPIY	ITCH	73:76	Mutation rewiring degron network	0.3056
p.V77L	TCGA-W5-AA34	CHOL	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.N89S	TCGA-XF-A9T0	BLCA	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.N89S	DO51920	BLCA	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.A737V	DO233759	GACA	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1667
p.V72L	DO228974	LICA	ICGC	PPIY	ITCH	73:76	Mutation rewiring degron network	0.3056
p.V72L	DO228974	LICA	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.1667
p.A755V	DO229054	LICA	ICGC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1389
p.P64L	DO46905	RECA	ICGC	PPIY	ITCH	73:76	Mutation rewiring degron network	0.0833
p.G295C	SIDM01951	Colorectal Carcinoma	GDSC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.3056
p.I75M	SIDM00636	Non-Cancerous	GDSC	PPIY	ITCH	73:76	Mutation altering degron motif	0.6507
p.I75M	ACH-001533	Lymphoma	CCLE	PPIY	ITCH	73:76	Mutation altering degron motif	0.6507
p.I75M	ACH-002270	Non-Cancerous	CCLE	PPIY	ITCH	73:76	Mutation altering degron motif	0.6507
p.I75M	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	73:76	Mutation altering degron motif	0.6507
p.S314G	SIDM01113	Other Sarcomas	GDSC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.0833
p.S314G	SK-UT-1	soft tissue	COSMIC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.0833
p.E309A	SIDM01588	Endometrial Carcinoma	GDSC	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.2222
p.E309A	ACH-000993	Endometrial/Uterine Cancer	CCLE	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.2222
p.D751G	ACH-000246	Kidney Cancer	CCLE	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.25
p.Y306C	ACH-001656	Leukemia	CCLE	ETDESSVPEL	DEG_COP1_1	296:305	Mutation rewiring degron network	0.3056
p.G753E	639-V	urinary tract	COSMIC	FGPFSE	LIG_APCC_ABBA_1	743:748	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FNDC3A

UniProt ID: Q9Y2H6

Entrez ID: 22862

Protein name: Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FNDC3A in