DegronMD

Uniprot ID: Q9Y2H6

Source protein: Fibronectin type-III domain-containing protein 3A

Source gene: FNDC3A

Class: LIG_APCC_ABBA_1

Location: 743:748

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9919

ASA_SCORE: 77.2333

COIL: 0.7158

CONS_SCORE: 0.6197

DSS_SCORE: 0.284

HELIX: 0.0162

FCONS_SCORE: 0.9952

RIG_SCORE: 0.7106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R736C	TCGA-5M-AAT6	COAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	TCGA-AP-A1DV	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	TCGA-AX-A2HC	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	DO223703	COAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	DO232224	PBCA	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	DO43186	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	DO41572	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.R736C	ACH-001736	Leukemia	CCLE	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.E748K	TCGA-BR-8372	STAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.7022
p.E748K	DO47873	STAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.7022
p.L735R	TCGA-D1-A1NZ	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.1111
p.L735R	DO41536	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1111
p.N739D	TCGA-DI-A1BU	UCEC	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.2222
p.N739D	DO42023	UCEC	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.2222
p.D751V	TCGA-KL-8341	KICH	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.25
p.D751V	DO220349	KICH	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.25
p.G757V	TCGA-MP-A4T7	LUAD	TCGA	FGPFSE	LIG_APCC_ABBA_1	0.0833
p.G757V	DO45370	LUAD	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.0833
p.A737V	DO233759	GACA	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1667
p.A755V	DO229054	LICA	ICGC	FGPFSE	LIG_APCC_ABBA_1	0.1389
p.D751G	ACH-000246	Kidney Cancer	CCLE	FGPFSE	LIG_APCC_ABBA_1	0.25
p.G753E	639-V	urinary_tract	COSMIC	FGPFSE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	LIG_APCC_ABBA_1	743:748	FGPFSE	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons