DegronMD

Uniprot ID: Q9Y2H6

Source protein: Fibronectin type-III domain-containing protein 3A

Source gene: FNDC3A

Class: ITCH

Location: 73:76

E3 ligase: ITCH,NEDD4

DEGRON score: 0.947

ASA_SCORE: 85.775

COIL: 0.902

CONS_SCORE: 0.4074

DSS_SCORE: 0.3893

HELIX: 0.0183

FCONS_SCORE: 0.8552

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V77L	TCGA-W5-AA34	CHOL	TCGA	PPIY	ITCH	0.3056
p.V72L	DO228974	LICA	ICGC	PPIY	ITCH	0.3056
p.P64L	DO46905	RECA	ICGC	PPIY	ITCH	0.0833
p.I75M	SIDM00636	Non-Cancerous	GDSC	PPIY	ITCH	0.6507
p.I75M	ACH-001533	Lymphoma	CCLE	PPIY	ITCH	0.6507
p.I75M	ACH-002270	Non-Cancerous	CCLE	PPIY	ITCH	0.6507
p.I75M	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	PPIY	ITCH	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons