DegronMD - Q15303(ERBB4)

FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1025S	TCGA-18-3409	LUSC	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1389
p.P1092S	TCGA-21-1075	LUSC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.L713F	TCGA-21-1083	LUSC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.L713F	TCGA-CN-4734	HNSC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.L713F	TCGA-L5-A4OE	ESCA	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.V1308L	TCGA-39-5034	LUSC	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1389
p.E1090D	TCGA-46-3765	LUSC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1090D	TCGA-VQ-A8P3	STAD	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1090D	SIDM00664	Pancreatic Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1090D	ACH-000178	Pancreatic Cancer	CCLE	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1090D	Hs766T	pancreas	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.V1134L	TCGA-49-AAR9	LUAD	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.2778
p.D1042Y	TCGA-55-6969	LUAD	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1389
p.D1131Y	TCGA-56-8305	LUSC	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.6214
p.R1304L	TCGA-68-7757	LUSC	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.25
p.R1304L	TCGA-78-7148	LUAD	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.25
p.L1023S	TCGA-77-8154	LUSC	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.L1023S	TCGA-FI-A2D5	UCEC	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.H1303Q	TCGA-80-5608	LUAD	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2778
p.H1303Q	TCGA-A3-A8OX	KIRC	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2778
p.S1037C	TCGA-A3-A6NJ	KIRC	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2778
p.P1292S	TCGA-A8-A08A	BRCA	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1667
p.S1043L	TCGA-AP-A056	UCEC	TCGA	PPIY	ITCH	1032:1035	Mutation blocking phosphorylation signal	0.5556
p.S1043L	TCGA-AP-A056	UCEC	TCGA	PPAY	ITCH	1053:1056	Mutation blocking phosphorylation signal	0.5
p.S1043L	TCGA-BK-A6W3	UCEC	TCGA	PPIY	ITCH	1032:1035	Mutation blocking phosphorylation signal	0.5556
p.S1043L	TCGA-BK-A6W3	UCEC	TCGA	PPAY	ITCH	1053:1056	Mutation blocking phosphorylation signal	0.5
p.L694V	TCGA-AP-A0LM	UCEC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.25
p.A1094T	TCGA-AX-A1CE	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1389
p.K1291N	TCGA-B5-A0JY	UCEC	TCGA	PPPY	ITCH	1298:1301	Mutation substituting flanking lysine	0.25
p.A1083V	TCGA-B5-A0JY	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.5825
p.A1083V	SIDM01228	Melanoma	GDSC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.5825
p.A1083V	ACH-001024	Skin Cancer	CCLE	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.5825
p.A1083V	CHL-1	skin	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.5825
p.T703K	TCGA-B6-A0RG	BRCA	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.7306
p.R711L	TCGA-BA-6872	HNSC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-BF-AAOX	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-BS-A0TC	UCEC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-DA-A95Z	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-EB-A430	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-EO-A3AV	UCEC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-FS-A1ZA	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.R711C	TCGA-GN-A4U4	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.P1300S	TCGA-BF-AAP4	SKCM	TCGA	PPPY	ITCH	1298:1301	Mutation altering degron motif	0.5641
p.A1039T	TCGA-BK-A6W3	UCEC	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2222
p.L710R	TCGA-BR-7958	STAD	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1389
p.H1118R	TCGA-BR-8372	STAD	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.2222
p.E693D	TCGA-BS-A0UV	UCEC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.2222
p.I1048T	TCGA-CA-6717	COAD	TCGA	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1944
p.P1132S	TCGA-CD-8524	STAD	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.6752
p.Q1063K	TCGA-CD-A48A	STAD	TCGA	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1389
p.N1062H	TCGA-CN-6024	HNSC	TCGA	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1667
p.P1054H	TCGA-CW-6093	KIRC	TCGA	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.7694
p.R1142Q	TCGA-D3-A2J8	SKCM	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.0556
p.S1086R	TCGA-D5-6924	COAD	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7427
p.Y1022C	TCGA-D8-A1XK	BRCA	TCGA	PPIY	ITCH	1032:1035	Mutation blocking phosphorylation signal	0.5
p.R1304W	TCGA-DF-A2KU	UCEC	TCGA	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.25
p.R687I	TCGA-DQ-5629	HNSC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.N1029D	TCGA-E7-A5KE	BLCA	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.25
p.E691K	TCGA-EB-A299	SKCM	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1667
p.P1117L	TCGA-EE-A29L	SKCM	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1944
p.R1127K	TCGA-EE-A2GI	SKCM	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.6126
p.E1047K	TCGA-EE-A3AA	SKCM	TCGA	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1667
p.I712S	TCGA-EO-A3B0	UCEC	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0833
p.P1053L	TCGA-ER-A42L	SKCM	TCGA	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.7582
p.P1031L	TCGA-FJ-A3ZF	BLCA	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.3056
p.P1300L	TCGA-FU-A5XV	CESC	TCGA	PPPY	ITCH	1298:1301	Mutation altering degron motif	0.6471
p.N1044D	TCGA-IB-7651	PAAD	TCGA	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.N1044D	TCGA-IB-7651	PAAD	TCGA	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.0833
p.P697S	TCGA-IB-7651	PAAD	TCGA	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.6752
p.Y1128H	TCGA-MA-AA42	CESC	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.834
p.Q1095L	TCGA-NC-A5HT	LUSC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1111
p.P1137A	TCGA-QK-A8ZA	HNSC	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1944
p.P1080S	TCGA-SL-A6JA	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.S1140I	TCGA-UB-AA0U	LIHC	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation blocking phosphorylation signal	0.5556
p.G1076E	TCGA-UY-A9PH	BLCA	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1389
p.R1139Q	TCGA-WE-A8K4	SKCM	TCGA	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1389
p.R1139Q	ACH-002508	Skin Cancer	CCLE	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1389
p.P1080L	TCGA-WE-A8K4	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.G1066E	DO223594	BLCA	ICGC	PPAY	ITCH	1053:1056	Mutation blocking phosphorylation signal	0.5
p.R701C	DO1146	BRCA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO229177	LMS	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO220877	MELA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO222402	MELA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO37551	SKCM	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO37906	SKCM	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO223907	SKCM	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO51256	SKCM	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO219481	SKCM	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO52412	UCEC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.R701C	DO42400	UCEC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8301
p.T693K	DO2353	BRCA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.2222
p.E1134Q	DO2401	BRCA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.2778
p.Q1116K	DO222541	BTCA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1667
p.Y1056H	DO229363	BTCA	ICGC	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.834
p.Y1118H	DO219724	CESC	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.2222
p.P1290L	DO48996	CESC	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1111
p.S1076R	DO7922	COAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1389
p.I1038T	DO8264	COAD	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.25
p.I1091M	DO8264	COAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.2222
p.F1092V	DO8256	COAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.P687A	DO230309	COCA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.A1045T	DO227993	COCA	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0556
p.A1045T	DO227993	COCA	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1111
p.F1092C	DO50345	ESAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.F1092C	DO230950	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.F1092C	DO224638	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.F1092C	DO38463	STAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.F1092C	DO47779	STAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.E1080D	DO234299	ESAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1080D	DO26959	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.E1080D	DO51762	STAD	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.K712N	DO234461	ESAD	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0833
p.E1064D	DO223095	ESCA	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1111
p.L700P	DO217822	GACA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.7582
p.T1075P	DO233103	GACA	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1111
p.T1075P	DO233191	GACA	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1111
p.T1123N	DO233202	GACA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7055
p.F1092Y	DO233718	GACA	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1944
p.R1294W	DO233749	GACA	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2222
p.R1294W	DO223286	UCEC	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2222
p.E1134K	DO233884	GACA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.2778
p.E1090V	DO14454	HNSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.25
p.L703F	DO15446	HNSC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.6981
p.L703F	DO26769	LUSC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.6981
p.N1052H	DO15326	HNSC	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.3056
p.R701L	DO14236	HNSC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8428
p.P1127A	DO52099	HNSC	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7503
p.H1293Q	DO49690	KIRC	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1944
p.H1293Q	DO23693	LUAD	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1944
p.S1027C	DO50457	KIRC	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1944
p.P1044H	DO16248	KIRC	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.P1044H	DO16248	KIRC	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.0833
p.D1112E	DO231955	LICA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.0556
p.P1131Q	DO228976	LICA	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7035
p.P1074Q	DO229026	LICA	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.0833
p.S1130I	DO52323	LIHC	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7341
p.D1032Y	DO24586	LUAD	ICGC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.7325
p.E707D	DO49875	LUAD	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.2222
p.V711L	DO218922	LUAD	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1111
p.V1124L	DO218921	LUAD	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.6765
p.R1294L	DO26112	LUAD	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2222
p.R1294L	DO26886	LUSC	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.2222
p.V1298L	DO26854	LUSC	ICGC	PPPY	ITCH	1298:1301	Mutation altering degron motif	0.6765
p.P1082S	DO26484	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.3056
p.T1088N	DO26689	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.3056
p.D1121Y	DO223725	LUSC	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.3056
p.M1141I	DO219182	LUSC	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.0833
p.Q1085L	DO219205	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7765
p.Q1053K	DO220858	MELA	ICGC	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.6944
p.Q1053K	DO47781	STAD	ICGC	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.6944
p.G1060S	DO220877	MELA	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2222
p.P1023T	DO220903	MELA	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.E1037K	DO222632	MELA	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2778
p.E1037K	DO37571	SKCM	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2778
p.R1028T	DO50694	ORCA	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2222
p.N1034D	DO46657	PAAD	ICGC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.6932
p.P687S	DO46657	PAAD	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.Q697H	DO35082	PACA	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.7582
p.G1059E	DO229459	SKCA	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.25
p.R1132Q	DO37778	SKCM	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7329
p.R1117K	DO37410	SKCM	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1944
p.P1043L	DO223910	SKCM	ICGC	PPIY	ITCH	1032:1035	Mutation blocking phosphorylation signal	0.5556
p.P1043L	DO223910	SKCM	ICGC	PPAY	ITCH	1053:1056	Mutation blocking phosphorylation signal	0.5
p.R1129Q	DO51281	SKCM	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.7329
p.P1290S	DO219468	SKCM	ICGC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.1111
p.Y1140C	DO38743	STAD	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation blocking phosphorylation signal	0.5556
p.P1122S	DO47787	STAD	ICGC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation altering degron motif	0.6752
p.L700R	DO38344	STAD	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.8428
p.S1095C	DO48147	THCA	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1111
p.I702S	DO219773	UCEC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation altering degron motif	0.7341
p.S1033L	DO50076	UCEC	ICGC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.7667
p.S1033L	DO43971	UCEC	ICGC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.7667
p.A1029T	DO50076	UCEC	ICGC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.25
p.A1084T	DO42280	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7139
p.A1073V	DO43041	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.0556
p.V713I	DO52402	UCEC	ICGC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.0556
p.G1060C	DO42713	UCEC	ICGC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2222
p.V1115M	SIDM01951	Colorectal Carcinoma	GDSC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1389
p.G1049E	SIDM01248	Thyroid Gland Carcinoma	GDSC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2222
p.G1049E	ACH-001023	Thyroid Cancer	CCLE	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2222
p.G1049E	CGTH-W-1	thyroid	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2222
p.P1058R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2778
p.P1058R	ACH-002263	Esophageal Cancer	CCLE	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2778
p.P1058R	KYSE-220	oesophagus	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2778
p.R1045G	SIDM00693	Bladder Carcinoma	GDSC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0556
p.R1045G	SIDM00693	Bladder Carcinoma	GDSC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1111
p.R1045G	ACH-000396	Bladder Cancer	CCLE	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0556
p.R1045G	ACH-000396	Bladder Cancer	CCLE	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1111
p.R1045G	J82	urinary tract	COSMIC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0556
p.R1045G	J82	urinary tract	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1111
p.Y1081N	SIDM00231	Kidney Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation blocking phosphorylation signal	0.7222
p.Y1081N	ACH-002167	Kidney Cancer	CCLE	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation blocking phosphorylation signal	0.7222
p.Y1081N	NCC010	kidney	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation blocking phosphorylation signal	0.7222
p.P1297L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.3056
p.P1297L	ACH-001669	Leukemia	CCLE	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.3056
p.P1297L	ACH-002238	Leukemia	CCLE	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.3056
p.P1297L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1298:1301	Mutation rewiring degron network	0.3056
p.L710P	SIDM00221	Melanoma	GDSC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1389
p.L710P	ACH-002388	Skin Cancer	CCLE	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1389
p.A1083S	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7588
p.A1083S	ACH-000596	Lung Cancer	CCLE	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7588
p.A1083S	LCLC-97TM1	lung	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7588
p.Y1035H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.834
p.Y1035H	ACH-000951	Lung Cancer	CCLE	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.834
p.Y1035H	NCI-H2342	lung	COSMIC	PPIY	ITCH	1032:1035	Mutation altering degron motif	0.834
p.P1114L	SIDM00243	Other Solid Cancers	GDSC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1111
p.P1114L	ACH-002288	Embryonal Cancer	CCLE	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1111
p.P1114L	NEC8	testis	COSMIC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1111
p.N1062S	SIDM00500	Colorectal Carcinoma	GDSC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1667
p.N1044S	ACH-000611	Lymphoma	CCLE	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.0833
p.N1044S	ACH-000611	Lymphoma	CCLE	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.0833
p.P1299L	ACH-000894	Lung Cancer	CCLE	PPPY	ITCH	1298:1301	Mutation altering degron motif	0.7582
p.P1299L	NCI-H1869	lung	COSMIC	PPPY	ITCH	1298:1301	Mutation altering degron motif	0.7582
p.N1062K	ACH-001366	Neuroblastoma	CCLE	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1667
p.E1084D	NCI-H2029	lung	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.6758
p.T690S	IHH-4	thyroid	COSMIC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1389
p.G704R	COLO-792	skin	COSMIC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.3056
p.Y1039N	NCC010	kidney	COSMIC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.2222
p.E1074D	Hs766T	pancreas	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.0833
p.Y1065N	NCC010	kidney	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.0833
p.E1048D	Hs766T	pancreas	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.1944
p.E1058D	NCI-H2029	lung	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2778
p.G1053V	SNU-1040	large intestine	COSMIC	PPAY	ITCH	1053:1056	Mutation altering degron motif	0.7532
p.G1093C	SAS	upper aerodigestive tract	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation rewiring degron network	0.1667
p.K708E	SK-MEL-31	skin	COSMIC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.1944
p.E1084V	REH	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	1083:1087	Mutation altering degron motif	0.7693
p.M1138V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.1667
p.A1041S	LCLC-97TM1	lung	COSMIC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1667
p.A1041V	CHL-1	skin	COSMIC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1667
p.G1027V	SNU-1040	large intestine	COSMIC	PPIY	ITCH	1032:1035	Mutation rewiring degron network	0.1944
p.M1112V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSSTQRYSADP	CBL_PTK	1122:1132	Mutation rewiring degron network	0.0556
p.G704E	COLO-792	skin	COSMIC	PLTPSGT	DEG_SCF_FBW7_1	697:703	Mutation rewiring degron network	0.3056
p.E1058V	REH	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	1053:1056	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERBB4

UniProt ID: Q15303

Entrez ID: 2066

Protein name: Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERBB4 in