DegronMD

Uniprot ID: Q15303

Source protein: Receptor tyrosine-protein kinase erbB-4

Source gene: ERBB4

Class: ITCH

Location: 1032:1035

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9911

ASA_SCORE: 92.3

COIL: 0.9478

CONS_SCORE: 0.2778

DSS_SCORE: 0.4424

HELIX: 0.0255

FCONS_SCORE: 0.9252

RIG_SCORE: 0.7398

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1025S	TCGA-18-3409	LUSC	TCGA	PPIY	ITCH	0.1389
p.D1042Y	TCGA-55-6969	LUAD	TCGA	PPIY	ITCH	0.1389
p.L1023S	TCGA-77-8154	LUSC	TCGA	PPIY	ITCH	0.0833
p.L1023S	TCGA-FI-A2D5	UCEC	TCGA	PPIY	ITCH	0.0833
p.S1037C	TCGA-A3-A6NJ	KIRC	TCGA	PPIY	ITCH	0.2778
p.S1043L	TCGA-AP-A056	UCEC	TCGA	PPIY	ITCH	0.5556
p.S1043L	TCGA-BK-A6W3	UCEC	TCGA	PPIY	ITCH	0.5556
p.A1039T	TCGA-BK-A6W3	UCEC	TCGA	PPIY	ITCH	0.2222
p.Y1022C	TCGA-D8-A1XK	BRCA	TCGA	PPIY	ITCH	0.5
p.N1029D	TCGA-E7-A5KE	BLCA	TCGA	PPIY	ITCH	0.25
p.P1031L	TCGA-FJ-A3ZF	BLCA	TCGA	PPIY	ITCH	0.3056
p.N1044D	TCGA-IB-7651	PAAD	TCGA	PPIY	ITCH	0.0833
p.I1038T	DO8264	COAD	ICGC	PPIY	ITCH	0.25
p.A1045T	DO227993	COCA	ICGC	PPIY	ITCH	0.0556
p.S1027C	DO50457	KIRC	ICGC	PPIY	ITCH	0.1944
p.P1044H	DO16248	KIRC	ICGC	PPIY	ITCH	0.0833
p.D1032Y	DO24586	LUAD	ICGC	PPIY	ITCH	0.7325
p.P1023T	DO220903	MELA	ICGC	PPIY	ITCH	0.0833
p.E1037K	DO222632	MELA	ICGC	PPIY	ITCH	0.2778
p.E1037K	DO37571	SKCM	ICGC	PPIY	ITCH	0.2778
p.R1028T	DO50694	ORCA	ICGC	PPIY	ITCH	0.2222
p.N1034D	DO46657	PAAD	ICGC	PPIY	ITCH	0.6932
p.P1043L	DO223910	SKCM	ICGC	PPIY	ITCH	0.5556
p.S1033L	DO50076	UCEC	ICGC	PPIY	ITCH	0.7667
p.S1033L	DO43971	UCEC	ICGC	PPIY	ITCH	0.7667
p.A1029T	DO50076	UCEC	ICGC	PPIY	ITCH	0.25
p.R1045G	SIDM00693	Bladder Carcinoma	GDSC	PPIY	ITCH	0.0556
p.R1045G	ACH-000396	Bladder Cancer	CCLE	PPIY	ITCH	0.0556
p.R1045G	J82	urinary_tract	COSMIC	PPIY	ITCH	0.0556
p.Y1035H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPIY	ITCH	0.834
p.Y1035H	ACH-000951	Lung Cancer	CCLE	PPIY	ITCH	0.834
p.Y1035H	NCI-H2342	lung	COSMIC	PPIY	ITCH	0.834
p.N1044S	ACH-000611	Lymphoma	CCLE	PPIY	ITCH	0.0833
p.Y1039N	NCC010	kidney	COSMIC	PPIY	ITCH	0.2222
p.A1041S	LCLC-97TM1	lung	COSMIC	PPIY	ITCH	0.1667
p.A1041V	CHL-1	skin	COSMIC	PPIY	ITCH	0.1667
p.G1027V	SNU-1040	large_intestine	COSMIC	PPIY	ITCH	0.1944

Drug responses associated with ERBB4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	CI-1033	625.7219
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	PF-00299804	634.8413
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	AST-1306	607.8213
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	AST-1306	0.2247
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	AST-1306	0.2247
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	CI-1033	1.6259
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	PF-00299804	0.9758
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	AST-1306	4.8215
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	CI-1033	11.7349
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	PF-00299804	20.7714
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	AST-1306	11.4067
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	CI-1033	7.6901
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	PF-00299804	6.6906
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	AST-1306	8.6121
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	CI-1033	4.9765
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	PF-00299804	2.5703
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	AST-1306	5.3078
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	CI-1033	12.0365
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	PF-00299804	4.0679
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	AST-1306	5.0729
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	CI-1033	13.1536
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	PF-00299804	13.0157
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	AST-1306	27.4993
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	CI-1033	280.2049
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	PF-00299804	172.5797
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	AST-1306	251.9199
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	CI-1033	52.3177
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	PF-00299804	9.1914
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	AST-1306	9.9412
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	CI-1033	3.0971
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	PF-00299804	1.6503
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	AST-1306	3.0199
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	CI-1033	121.4984
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	PF-00299804	77.9236
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	AST-1306	13.6513
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	CI-1033	5.1399
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	PF-00299804	2.2239
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	AST-1306	3.9816
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	16.3474
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	16.5693
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	13.2789
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	CI-1033	1.8076
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	PF-00299804	0.8176
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	AST-1306	0.4803
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	CI-1033	3.2379
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	PF-00299804	8.513
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	AST-1306	3.0479
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	CI-1033	12.5763
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	PF-00299804	21.7285
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	AST-1306	7.7801
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	CI-1033	2.4348
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	PF-00299804	1.3046
SIDM00551	ESCA\|oesophagus	p.P1058R (No)	GDSC	AST-1306	2.5895
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	CI-1033	1228.0969
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	PF-00299804	118.7014
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	AST-1306	35.2199
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	CI-1033	10.5003
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	PF-00299804	8.0399
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	AST-1306	7.928
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	CI-1033	2.2569
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	PF-00299804	1.5015
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	AST-1306	0.2762
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	CI-1033	3.9782
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	PF-00299804	4.7819
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	AST-1306	3.6829
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	CI-1033	10.1065
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	PF-00299804	19.2743
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	AST-1306	10.7208
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	CI-1033	9.3187
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	PF-00299804	4.5029
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	AST-1306	4.1386
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	CI-1033	14.0918
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	PF-00299804	2.9404
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	AST-1306	4.7326
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	CI-1033	4.6485
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	PF-00299804	9.6739
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	AST-1306	5.7254
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	CI-1033	3.444
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	PF-00299804	2.3879
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	AST-1306	0.6832
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	CI-1033	2.5945
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	PF-00299804	7.3201
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	AST-1306	0.4299
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	AST-1306	4.4781
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	AST-1306	3.4539
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	CI-1033	46.2567
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	PF-00299804	9.5139
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	AST-1306	6.1981
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	CI-1033	2.9011
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	PF-00299804	2.3614
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	AST-1306	2.6068
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	CI-1033	1.6738
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	PF-00299804	11.8734
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	AST-1306	1.529
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	AST-1306	0.9173
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	AST-1306	0.9173
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	CI-1033	2.3204
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	PF-00299804	2.0335
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	AST-1306	4.1598
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	2.15
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	1.4193
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	2.2393
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	CI-1033	2.1216
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	PF-00299804	2.2222
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	AST-1306	2.318
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	CI-1033	0.7093
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	PF-00299804	1.3321
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	AST-1306	1.0731
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	AST-1306	6.4973
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	AST-1306	6.4973
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	CI-1033	9.1671
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	PF-00299804	3.2101
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	AST-1306	2.114
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	AST-1306	13.2253
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	AST-1306	13.2253
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	AST-1306	12.0816
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	AST-1306	12.0816
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	CI-1033	4.4545
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	PF-00299804	3.6922
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	AST-1306	4.0123
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	CI-1033	24.105
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	PF-00299804	8.29
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	AST-1306	4.0648
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	AST-1306	8.4474
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	AST-1306	8.4474
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	CI-1033	21.0255
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	PF-00299804	7.2815
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	AST-1306	6.6768
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	CI-1033	13.1189
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	PF-00299804	10.0964
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	AST-1306	6.4315
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	CI-1033	287.8976
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	PF-00299804	36.7024
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	AST-1306	106.2904
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	CI-1033	13.8474
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	PF-00299804	9.5661
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	AST-1306	6.8615
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	CI-1033	17.1343
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	PF-00299804	7.6388
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	AST-1306	76.4825
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	CI-1033	51.0403
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	PF-00299804	15.2578
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	AST-1306	23.595
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	CI-1033	45.3419
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	PF-00299804	23.2993
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	AST-1306	176.9086
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	CI-1033	8.2936
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	PF-00299804	4.2259
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	AST-1306	6.282
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	CI-1033	193.7807
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	PF-00299804	7.9634
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	AST-1306	25.9277
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	CI-1033	1.5327
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	PF-00299804	1.7431
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	AST-1306	1.4418
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	AST-1306	19.1221
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	CI-1033	0.1143
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	PF-00299804	0.0699
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	AST-1306	0.3311
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	CI-1033	19.3737
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	PF-00299804	10.4193
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	AST-1306	5.2164
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	AST-1306	22.8082
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	AST-1306	22.8082
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	CI-1033	1.2152
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	PF-00299804	2.3276
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	AST-1306	1.9704
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (Yes)	GDSC	CI-1033	3.2855
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (Yes)	GDSC	PF-00299804	4.9834
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (Yes)	GDSC	AST-1306	2.3638
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	CI-1033	7.3798
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	PF-00299804	16.2748
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	AST-1306	11.234
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	CI-1033	4.7495
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	PF-00299804	4.4903
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	AST-1306	5.4567
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	CI-1033	4.9793
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	PF-00299804	3.0583
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	AST-1306	4.9432
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	CI-1033	9.915
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	PF-00299804	9.1385
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	AST-1306	3.873
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	CI-1033	0.679
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	PF-00299804	0.5715
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	AST-1306	0.8778
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	AST-1306	6.1738
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	AST-1306	6.1738
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	CI-1033	51.2544
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	PF-00299804	29.8756
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	AST-1306	11.7866
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	CI-1033	189.7676
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	PF-00299804	85.3776
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	AST-1306	15.4504
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	CI-1033	8.2213
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	PF-00299804	12.8214
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	AST-1306	7.0898
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	AST-1306	3.5929
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	AST-1306	3.5929
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	CI-1033	2.5374
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	PF-00299804	0.3855
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	AST-1306	0.3323
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	CI-1033	39.6122
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	PF-00299804	13.0985
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	AST-1306	10.6559
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	CI-1033	0.1344
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	PF-00299804	0.1055
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	AST-1306	0.1053
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	CI-1033	10.9899
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	PF-00299804	14.6331
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	AST-1306	1.9208
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	CI-1033	7.1841
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	PF-00299804	9.4837
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	AST-1306	3.9102
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	CI-1033	26.5943
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	PF-00299804	7.2571
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	AST-1306	5.7931
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	CI-1033	0.7557
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	PF-00299804	4.3875
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	AST-1306	5.0071
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	CI-1033	7.6005
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	PF-00299804	7.1883
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	AST-1306	6.9505
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	CI-1033	0.2481
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	PF-00299804	0.5468
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	AST-1306	0.4875
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	CI-1033	2.2418
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	PF-00299804	1.7179
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	AST-1306	0.9416
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	CI-1033	37.7483
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	PF-00299804	47.4842
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	AST-1306	9.4265
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	CI-1033	36.8096
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	PF-00299804	18.9073
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	AST-1306	19.9553
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	CI-1033	3.7518
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	PF-00299804	2.5396
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	AST-1306	7.9178
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	CI-1033	2.9775
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	PF-00299804	2.9577
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	AST-1306	3.9355
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	AST-1306	4.613
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	AST-1306	4.613
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	CI-1033	30.452
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	PF-00299804	16.2561
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	AST-1306	12.8772
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	CI-1033	8.4237
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	PF-00299804	22.8686
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	AST-1306	16.8593
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	CI-1033	6.7985
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	PF-00299804	9.5939
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	AST-1306	3.7294
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	AST-1306	27.6776
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	CI-1033	8.2727
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	PF-00299804	7.2249
SIDM01248	THCA\|thyroid	p.G1049E (No)	GDSC	AST-1306	7.1822

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPIY

Degron related mutations and impact score

Drug responses associated with ERBB4 mutations

All proteins holding degron of PPIY