DegronMD - O43281(EFS)

FUNCTION: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.

GO - Biological processes (BP): actin filament reorganization [GO:0090527]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

GO - Molecular function (MF): protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124]

GO - Cellular component (CC): cytoplasm [GO:0005737]; focal adhesion [GO:0005925]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R314C	ESS-1	endometrium	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.8301
p.R304H	TCGA-CM-6674	COAD	TCGA	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.8244
p.R304H	DO10092	COAD	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.8244
p.P214H	SIDM00863	Burkitt's Lymphoma	GDSC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7694
p.P214H	EB2	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7694
p.P305L	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.7582
p.R324Q	SNU-1040	large intestine	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.7329
p.R305H	DO227504	LAML	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.7133
p.P215T	TCGA-BR-8361	STAD	TCGA	PPIY	ITCH	214:217	Mutation altering degron motif	0.7031
p.P215T	DO48032	STAD	ICGC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7031
p.P322S	TCGA-AZ-4315	COAD	TCGA	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P322S	DO8842	COAD	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P324S	TCGA-FR-A726	SKCM	TCGA	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P324S	DO48665	SKCM	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.S319P	DO229272	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.I216M	TCGA-IQ-A61E	HNSC	TCGA	PPIY	ITCH	214:217	Mutation altering degron motif	0.6507
p.I216M	DO44429	HNSC	ICGC	PPIY	ITCH	214:217	Mutation altering degron motif	0.6507
p.E314D	ACH-001369	Ovarian Cancer	CCLE	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.5647
p.P316S	ACH-001973	Metastasis	CCLE	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.5641
p.D312N	NCI-H650	lung	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 50 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFS

UniProt ID: O43281

Entrez ID: 10278

Protein name: Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFS in