DegronMD - O43281(EFS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A226V	TCGA-36-2534	OV	TCGA	PPIY	ITCH	214:217	Mutation rewiring degron network	0.0833
p.A226V	TCGA-AX-A0J1	UCEC	TCGA	PPIY	ITCH	214:217	Mutation rewiring degron network	0.0833
p.A226V	DO23408	LINC	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.0833
p.A226V	DO29046	OV	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.0833
p.A226V	DO41199	UCEC	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.0833
p.P322S	TCGA-AZ-4315	COAD	TCGA	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P322S	DO8842	COAD	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P215T	TCGA-BR-8361	STAD	TCGA	PPIY	ITCH	214:217	Mutation altering degron motif	0.7031
p.P215T	DO48032	STAD	ICGC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7031
p.E211K	TCGA-BT-A42C	BLCA	TCGA	PPIY	ITCH	214:217	Mutation rewiring degron network	0.25
p.E211K	TCGA-IQ-A61E	HNSC	TCGA	PPIY	ITCH	214:217	Mutation rewiring degron network	0.25
p.E211K	DO49725	BLCA	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.25
p.E211K	DO223002	ESCA	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.25
p.E211K	DO44429	HNSC	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.25
p.R304H	TCGA-CM-6674	COAD	TCGA	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.8244
p.R304H	DO10092	COAD	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.8244
p.P324S	TCGA-FR-A726	SKCM	TCGA	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.P324S	DO48665	SKCM	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.I216M	TCGA-IQ-A61E	HNSC	TCGA	PPIY	ITCH	214:217	Mutation altering degron motif	0.6507
p.I216M	DO44429	HNSC	ICGC	PPIY	ITCH	214:217	Mutation altering degron motif	0.6507
p.R225L	TCGA-KQ-A41N	BLCA	TCGA	PPIY	ITCH	214:217	Mutation rewiring degron network	0.1111
p.R225L	DO223588	BLCA	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.1111
p.R305H	DO227504	LAML	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.7133
p.A219D	DO229027	LICA	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.2778
p.P212T	DO229031	LICA	ICGC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.2778
p.S319P	DO229272	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.6752
p.R295W	DO229272	THCA	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.1111
p.G327C	DO229213	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.25
p.I332V	DO229250	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.1111
p.E300K	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.25
p.E300K	ACH-000861	Lung Cancer	CCLE	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.25
p.P214H	SIDM00863	Burkitt's Lymphoma	GDSC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7694
p.P214H	EB2	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	214:217	Mutation altering degron motif	0.7694
p.R328W	SIDM00951	T-Lymphoblastic Leukemia	GDSC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2222
p.R328W	ACH-002222	Leukemia	CCLE	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2222
p.R328W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2222
p.E207K	SIDM00679	Cervical Carcinoma	GDSC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.1389
p.E207K	ACH-001525	Cervical Cancer	CCLE	PPIY	ITCH	214:217	Mutation rewiring degron network	0.1389
p.E207K	HT-3	cervix	COSMIC	PPIY	ITCH	214:217	Mutation rewiring degron network	0.1389
p.R328Q	SIDM01609	Endometrial Carcinoma	GDSC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2222
p.E314D	ACH-001369	Ovarian Cancer	CCLE	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.5647
p.P316S	ACH-001973	Metastasis	CCLE	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.5641
p.A326V	SNU-1040	large intestine	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2778
p.R314C	ESS-1	endometrium	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.8301
p.D312N	NCI-H650	lung	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.3056
p.D312N	NCI-H650	lung	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation rewiring degron network	0.2778
p.R299C	RL95-2	endometrium	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.2222
p.R299C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation rewiring degron network	0.2222
p.R324Q	SNU-1040	large intestine	COSMIC	EAPSPSPVPSP	DEG_COP1_1	314:324	Mutation altering degron motif	0.7329
p.P305L	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	303:311	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFS

UniProt ID: O43281

Entrez ID: 10278

Protein name: Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFS in