DegronMD

Uniprot ID: O43281

Source protein: Embryonal Fyn-associated substrate

Source gene: EFS

Class: DEG_COP1_1

Location: 314:324

E3 ligase: COP1

DEGRON score: 0.8991

ASA_SCORE: 82.9273

COIL: 0.9559

CONS_SCORE: 0.5271

DSS_SCORE: 0.7163

HELIX: 0.0151

FCONS_SCORE: 0.9123

RIG_SCORE: 0.4757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P322S	TCGA-AZ-4315	COAD	TCGA	EAPSPSPVPSP	DEG_COP1_1	0.6752
p.P322S	DO8842	COAD	ICGC	EAPSPSPVPSP	DEG_COP1_1	0.6752
p.P324S	TCGA-FR-A726	SKCM	TCGA	EAPSPSPVPSP	DEG_COP1_1	0.6752
p.P324S	DO48665	SKCM	ICGC	EAPSPSPVPSP	DEG_COP1_1	0.6752
p.S319P	DO229272	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	0.6752
p.G327C	DO229213	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	0.25
p.I332V	DO229250	THCA	ICGC	EAPSPSPVPSP	DEG_COP1_1	0.1111
p.R328W	SIDM00951	T-Lymphoblastic Leukemia	GDSC	EAPSPSPVPSP	DEG_COP1_1	0.2222
p.R328W	ACH-002222	Leukemia	CCLE	EAPSPSPVPSP	DEG_COP1_1	0.2222
p.R328W	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	EAPSPSPVPSP	DEG_COP1_1	0.2222
p.R328Q	SIDM01609	Endometrial Carcinoma	GDSC	EAPSPSPVPSP	DEG_COP1_1	0.2222
p.E314D	ACH-001369	Ovarian Cancer	CCLE	EAPSPSPVPSP	DEG_COP1_1	0.5647
p.P316S	ACH-001973	Metastasis	CCLE	EAPSPSPVPSP	DEG_COP1_1	0.5641
p.A326V	SNU-1040	large_intestine	COSMIC	EAPSPSPVPSP	DEG_COP1_1	0.2778
p.R314C	ESS-1	endometrium	COSMIC	EAPSPSPVPSP	DEG_COP1_1	0.8301
p.D312N	NCI-H650	lung	COSMIC	EAPSPSPVPSP	DEG_COP1_1	0.2778
p.R324Q	SNU-1040	large_intestine	COSMIC	EAPSPSPVPSP	DEG_COP1_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43281	Embryonal Fyn-associated substrate	DEG_COP1_1	314:324	EAPSPSPVPSP	COP1	0.8991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons