DegronMD

Uniprot ID: O43281

Source protein: Embryonal Fyn-associated substrate

Source gene: EFS

Class: DEG_APCC_DBOX_1

Location: 303:311

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9129

ASA_SCORE: 90.5778

COIL: 0.9053

CONS_SCORE: 0.6142

DSS_SCORE: 0.6596

HELIX: 0.0582

FCONS_SCORE: 1.171

RIG_SCORE: 0.571

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R304H	TCGA-CM-6674	COAD	TCGA	SRRPLPALP	DEG_APCC_DBOX_1	0.8244
p.R304H	DO10092	COAD	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	0.8244
p.P305L	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	0.7582
p.R305H	DO227504	LAML	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	0.7133
p.D312N	NCI-H650	lung	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	0.3056
p.E300K	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	SRRPLPALP	DEG_APCC_DBOX_1	0.25
p.E300K	ACH-000861	Lung Cancer	CCLE	SRRPLPALP	DEG_APCC_DBOX_1	0.25
p.R299C	RL95-2	endometrium	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	0.2222
p.R299C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLPALP	DEG_APCC_DBOX_1	0.2222
p.R295W	DO229272	THCA	ICGC	SRRPLPALP	DEG_APCC_DBOX_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43281	Embryonal Fyn-associated substrate	DEG_APCC_DBOX_1	303:311	SRRPLPALP	APC,CDC20,FZR1	0.9129	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons