DegronMD - O14639(ABLIM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R445W	TCGA-21-1079	LUSC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.R445W	TCGA-B5-A11E	UCEC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.R445W	DO26846	LUSC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.R445W	DO222837	MELA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.R445W	DO41644	UCEC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.P562L	TCGA-A5-A0G2	UCEC	TCGA	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7582
p.P562L	TCGA-CV-7568	HNSC	TCGA	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7582
p.P562L	DO14160	HNSC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7582
p.P562L	DO229459	SKCA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7582
p.P562L	DO41235	UCEC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7582
p.A533S	TCGA-AA-A01C	COAD	TCGA	PPIY	ITCH	525:528	Mutation rewiring degron network	0.1944
p.A533S	DO7781	COAD	ICGC	PPIY	ITCH	525:528	Mutation rewiring degron network	0.1944
p.A532S	TCGA-D3-A2JP	SKCM	TCGA	PPIY	ITCH	525:528	Mutation rewiring degron network	0.2222
p.A532S	DO47407	SKCM	ICGC	PPIY	ITCH	525:528	Mutation rewiring degron network	0.2222
p.Q440K	TCGA-DA-A1IB	SKCM	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.25
p.Q440K	DO38033	SKCM	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.25
p.R445Q	TCGA-DC-6158	READ	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.R445Q	DO37197	READ	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.M446T	TCGA-EV-5902	KIRP	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.0833
p.M446T	DO20875	KIRP	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.0833
p.K563N	TCGA-F5-6814	READ	TCGA	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.5806
p.K563N	DO36556	READ	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.5806
p.Y439C	TCGA-F7-A624	HNSC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation blocking phosphorylation signal	0.7222
p.Y439C	DO44440	HNSC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation blocking phosphorylation signal	0.7222
p.T566M	TCGA-J4-A67N	PRAD	TCGA	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.3056
p.T566M	DO233882	GACA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.3056
p.T566M	DO46807	PRAD	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.3056
p.P526S	DO222842	COCA	ICGC	PPIY	ITCH	525:528	Mutation altering degron motif	0.6752
p.G438W	DO233650	GACA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.3056
p.S548C	DO233723	GACA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.0556
p.E425V	DO231992	LICA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1944
p.P562Q	DO229045	LICA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.7035
p.G424E	DO229054	LICA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1667
p.D557E	DO229009	LICA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.3056
p.K563E	DO230550	LUSC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation altering degron motif	0.591
p.P572S	SIDM01175	Other Sarcomas	GDSC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.1389
p.P572S	ACH-002309	Sarcoma	CCLE	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.1389
p.P572S	SW684	soft tissue	COSMIC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.1389
p.G571D	SIDM01546	Kidney Carcinoma	GDSC	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.1667
p.G571D	ACH-000234	Kidney Cancer	CCLE	PSETPKIE	DEG_SCF_FBW7_2	558:565	Mutation rewiring degron network	0.1667
p.R523Q	ACH-001970	Metastasis	CCLE	PPIY	ITCH	525:528	Mutation rewiring degron network	0.2778
p.D447E	MKN7	stomach	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.0556
p.I515M	MDA-MB-361	breast	COSMIC	PPIY	ITCH	525:528	Mutation rewiring degron network	0.0556
p.T438M	22RV1	prostate	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.3056
p.R427Q	NCI-H82	lung	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.25
p.R440C	FTC-133	thyroid	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABLIM1

UniProt ID: O14639

Entrez ID: 3983

Protein name: Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABLIM1 in