DegronMD

Uniprot ID: O14639

Source protein: Actin-binding LIM protein 1

Source gene: ABLIM1

Class: DEG_SCF_FBW7_2

Location: 558:565

E3 ligase: FBXW7

DEGRON score: 0.768

ASA_SCORE: 80.275

COIL: 0.865

CONS_SCORE: 0.4117

DSS_SCORE: 0.7405

HELIX: 0.0984

FCONS_SCORE: 0.9664

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P562L	TCGA-A5-A0G2	UCEC	TCGA	PSETPKIE	DEG_SCF_FBW7_2	0.7582
p.P562L	TCGA-CV-7568	HNSC	TCGA	PSETPKIE	DEG_SCF_FBW7_2	0.7582
p.P562L	DO14160	HNSC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.7582
p.P562L	DO229459	SKCA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.7582
p.P562L	DO41235	UCEC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.7582
p.K563N	TCGA-F5-6814	READ	TCGA	PSETPKIE	DEG_SCF_FBW7_2	0.5806
p.K563N	DO36556	READ	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.5806
p.T566M	TCGA-J4-A67N	PRAD	TCGA	PSETPKIE	DEG_SCF_FBW7_2	0.3056
p.T566M	DO233882	GACA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.3056
p.T566M	DO46807	PRAD	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.3056
p.S548C	DO233723	GACA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.0556
p.P562Q	DO229045	LICA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.7035
p.D557E	DO229009	LICA	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.3056
p.K563E	DO230550	LUSC	ICGC	PSETPKIE	DEG_SCF_FBW7_2	0.591
p.P572S	SIDM01175	Other Sarcomas	GDSC	PSETPKIE	DEG_SCF_FBW7_2	0.1389
p.P572S	ACH-002309	Sarcoma	CCLE	PSETPKIE	DEG_SCF_FBW7_2	0.1389
p.P572S	SW684	soft_tissue	COSMIC	PSETPKIE	DEG_SCF_FBW7_2	0.1389
p.G571D	SIDM01546	Kidney Carcinoma	GDSC	PSETPKIE	DEG_SCF_FBW7_2	0.1667
p.G571D	ACH-000234	Kidney Cancer	CCLE	PSETPKIE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	DEG_SCF_FBW7_2	558:565	PSETPKIE	FBXW7	0.768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons