DegronMD

Uniprot ID: O14639

Source protein: Actin-binding LIM protein 1

Source gene: ABLIM1

Class: DEG_SCF_FBW7_2

Location: 430:437

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 68.4875

COIL: 0.8713

CONS_SCORE: 0.4065

DSS_SCORE: 0.7119

HELIX: 0.0579

FCONS_SCORE: 1.1027

RIG_SCORE: 0.6142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R445W	TCGA-21-1079	LUSC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.R445W	TCGA-B5-A11E	UCEC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.R445W	DO26846	LUSC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.R445W	DO222837	MELA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.R445W	DO41644	UCEC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.Q440K	TCGA-DA-A1IB	SKCM	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.25
p.Q440K	DO38033	SKCM	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.25
p.R445Q	TCGA-DC-6158	READ	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.R445Q	DO37197	READ	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1111
p.M446T	TCGA-EV-5902	KIRP	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.0833
p.M446T	DO20875	KIRP	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.0833
p.Y439C	TCGA-F7-A624	HNSC	TCGA	LSPTPSAE	DEG_SCF_FBW7_2	0.7222
p.Y439C	DO44440	HNSC	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.7222
p.G438W	DO233650	GACA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.3056
p.E425V	DO231992	LICA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1944
p.G424E	DO229054	LICA	ICGC	LSPTPSAE	DEG_SCF_FBW7_2	0.1667
p.D447E	MKN7	stomach	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	0.0556
p.T438M	22RV1	prostate	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	0.3056
p.R427Q	NCI-H82	lung	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	0.25
p.R440C	FTC-133	thyroid	COSMIC	LSPTPSAE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	DEG_SCF_FBW7_2	430:437	LSPTPSAE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons