DegronMD

Uniprot ID: Q6BDS2

Source protein: UHRF1-binding protein 1

Source gene: UHRF1BP1

Class: ITCH

Location: 1331:1334

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9895

ASA_SCORE: 77.175

COIL: 0.9475

CONS_SCORE: 0.6675

DSS_SCORE: 0.3852

HELIX: 0.0158

FCONS_SCORE: 1.1232

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1327N	TCGA-AX-A06F	UCEC	TCGA	PPIY	ITCH	0.3333
p.K1327N	DO41752	UCEC	ICGC	PPIY	ITCH	0.3333
p.G1339D	TCGA-F4-6856	COAD	TCGA	PPIY	ITCH	0.1944
p.G1339D	DO9114	COAD	ICGC	PPIY	ITCH	0.1944
p.G1339S	TCGA-FR-A726	SKCM	TCGA	PPIY	ITCH	0.1944
p.G1339S	DO48665	SKCM	ICGC	PPIY	ITCH	0.1944
p.S1337C	TCGA-ZF-AA4X	BLCA	TCGA	PPIY	ITCH	0.25
p.S1337C	DO219091	BLCA	ICGC	PPIY	ITCH	0.25
p.I1324V	DO48270	ESCA	ICGC	PPIY	ITCH	0.1389
p.G1339V	DO229029	LICA	ICGC	PPIY	ITCH	0.1944
p.D1329N	DO229257	THCA	ICGC	PPIY	ITCH	0.2778
p.T1336I	SIDM00290	Gastric Carcinoma	GDSC	PPIY	ITCH	0.7222
p.T1336I	SIDM00989	Bladder Carcinoma	GDSC	PPIY	ITCH	0.7222
p.T1336I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PPIY	ITCH	0.7222
p.T1336I	HGC-27	stomach	COSMIC	PPIY	ITCH	0.7222
p.T1336I	BFTC-905	urinary_tract	COSMIC	PPIY	ITCH	0.7222
p.Y1334C	ACH-000196	Breast Cancer	CCLE	PPIY	ITCH	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons