DegronMD - Q5TC82(RC3H1)

FUNCTION: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25504471, PubMed:25026078). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E695K	TCGA-55-7724	LUAD	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.1667
p.E695K	TCGA-AC-A23H	BRCA	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.1667
p.E695K	DO2401	BRCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.1667
p.E695K	DO45373	LUAD	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.1667
p.Y662F	TCGA-55-8094	LUAD	TCGA	PPIY	ITCH	663:666	Mutation blocking phosphorylation signal	0.75
p.Y662F	DO24150	LUAD	ICGC	PPIY	ITCH	663:666	Mutation blocking phosphorylation signal	0.75
p.I882M	TCGA-98-8021	LUSC	TCGA	LIPFGD	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.I882M	DO27468	LUSC	ICGC	LIPFGD	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.R673C	TCGA-AD-A5EJ	COAD	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.0556
p.R673C	TCGA-AD-A5EJ	COAD	TCGA	PPIY	ITCH	663:666	Mutation rewiring degron network	0.1389
p.R673C	DO50090	COAD	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.0556
p.R673C	DO50090	COAD	ICGC	PPIY	ITCH	663:666	Mutation rewiring degron network	0.1389
p.Q658H	TCGA-AP-A051	UCEC	TCGA	PPIY	ITCH	663:666	Mutation rewiring degron network	0.1944
p.Q658H	DO42673	UCEC	ICGC	PPIY	ITCH	663:666	Mutation rewiring degron network	0.1944
p.Q661R	TCGA-CD-8525	STAD	TCGA	PPIY	ITCH	663:666	Mutation rewiring degron network	0.2778
p.Q661R	DO47763	STAD	ICGC	PPIY	ITCH	663:666	Mutation rewiring degron network	0.2778
p.E685D	TCGA-D6-A4ZB	HNSC	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.5647
p.E685D	DO44446	HNSC	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.5647
p.R683K	TCGA-DK-AA76	BLCA	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.6126
p.R683K	DO219013	BLCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.6126
p.R857T	TCGA-FD-A43X	BLCA	TCGA	LIPFGD	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.R857T	DO44067	BLCA	ICGC	LIPFGD	LIG_APCC_ABBA_1	867:872	Mutation rewiring degron network	0.0556
p.R683T	DO52605	BOCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.7876
p.P659L	DO218863	SKCA	ICGC	PPIY	ITCH	663:666	Mutation rewiring degron network	0.2222
p.P697L	DO229248	THCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation rewiring degron network	0.1111
p.R688L	SIDM00292	Small Cell Lung Carcinoma	GDSC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.7316
p.R688L	ACH-002077	Lung Cancer	CCLE	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.7316
p.R688L	LU-165	lung	COSMIC	REEIFRE	LIG_APCC_ABBAyCdc20_2	683:689	Mutation altering degron motif	0.7316

Kaplan plot for RC3H1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RC3H1

UniProt ID: Q5TC82

Entrez ID: 149041

Protein name: Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RC3H1 in