DegronMD

Uniprot ID: Q5TC82

Source protein: Roquin-1

Source gene: RC3H1

Class: LIG_APCC_ABBA_1

Location: 867:872

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9823

ASA_SCORE: 51.2

COIL: 0.7947

CONS_SCORE: 0.4014

DSS_SCORE: 0.5192

HELIX: 0.0383

FCONS_SCORE: 0.9408

RIG_SCORE: 0.7501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I882M	TCGA-98-8021	LUSC	TCGA	LIPFGD	LIG_APCC_ABBA_1	0.0556
p.I882M	DO27468	LUSC	ICGC	LIPFGD	LIG_APCC_ABBA_1	0.0556
p.R857T	TCGA-FD-A43X	BLCA	TCGA	LIPFGD	LIG_APCC_ABBA_1	0.0556
p.R857T	DO44067	BLCA	ICGC	LIPFGD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TC82	Roquin-1	LIG_APCC_ABBA_1	867:872	LIPFGD	APC,CDC20,FZR1	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons