DegronMD

Uniprot ID: Q5TC82

Source protein: Roquin-1

Source gene: RC3H1

Class: LIG_APCC_ABBAyCdc20_2

Location: 683:689

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6065

ASA_SCORE: 94.2429

COIL: 0.4679

CONS_SCORE: 0.3817

DSS_SCORE: 0.4156

HELIX: 0.5074

FCONS_SCORE: 1.0564

RIG_SCORE: 0.7785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E695K	TCGA-55-7724	LUAD	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E695K	TCGA-AC-A23H	BRCA	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E695K	DO2401	BRCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E695K	DO45373	LUAD	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R673C	TCGA-AD-A5EJ	COAD	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R673C	DO50090	COAD	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E685D	TCGA-D6-A4ZB	HNSC	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E685D	DO44446	HNSC	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.5647
p.R683K	TCGA-DK-AA76	BLCA	TCGA	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R683K	DO219013	BLCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R683T	DO52605	BOCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.7876
p.P697L	DO229248	THCA	ICGC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R688L	SIDM00292	Small Cell Lung Carcinoma	GDSC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.7316
p.R688L	ACH-002077	Lung Cancer	CCLE	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.7316
p.R688L	LU-165	lung	COSMIC	REEIFRE	LIG_APCC_ABBAyCdc20_2	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TC82	Roquin-1	LIG_APCC_ABBAyCdc20_2	683:689	REEIFRE	APC,CDC20,FZR1	0.6065	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons