DegronMD - Q9NZR2(LRP1B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I4540V	TCGA-05-4389	LUAD	TCGA	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.5965
p.I4540V	DO24307	LUAD	ICGC	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.5965
p.R414K	TCGA-05-4424	LUAD	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1944
p.R414K	DO23672	LUAD	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1944
p.F4531L	TCGA-05-4430	LUAD	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1389
p.F4531L	DO23750	LUAD	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1389
p.A4537V	TCGA-06-5416	GBM	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	TCGA-AP-A0LM	UCEC	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	TCGA-BS-A0UV	UCEC	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	TCGA-VQ-A8PB	STAD	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	DO10880	GBM	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	DO51766	STAD	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	DO43306	UCEC	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537V	DO42793	UCEC	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.D432E	TCGA-22-1011	LUSC	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.D432E	DO26426	LUSC	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.L4533I	TCGA-44-8119	LUAD	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1944
p.L4533I	DO24399	LUAD	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1944
p.G4569W	TCGA-55-8204	LUAD	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25
p.G4569W	TCGA-WE-A8ZT	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25
p.G4569W	DO45322	LUAD	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25
p.G4569W	DO51290	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25
p.P4539H	TCGA-55-8621	LUAD	TCGA	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.7694
p.P4539H	DO25406	LUAD	ICGC	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.7694
p.I4540M	TCGA-58-8391	LUSC	TCGA	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.6507
p.I4540M	DO45440	LUSC	ICGC	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.6507
p.R4573L	TCGA-58-A46M	LUSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.8428
p.R4573L	DO45485	LUSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.8428
p.H4535N	TCGA-69-7974	LUAD	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.25
p.H4535N	DO23850	LUAD	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.25
p.N430I	TCGA-85-8481	LUSC	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1667
p.N430I	DO45465	LUSC	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1667
p.E4581G	TCGA-AG-3592	READ	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.3056
p.E4581G	DO37308	READ	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.3056
p.L416I	TCGA-AJ-A3EL	UCEC	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.L416I	TCGA-BR-4257	STAD	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.L416I	DO38683	STAD	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.L416I	DO41542	UCEC	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.S431Y	TCGA-AX-A0J0	UCEC	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.S431Y	DO41133	UCEC	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.S4544F	TCGA-D3-A2JE	SKCM	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.25
p.S4544F	DO219476	SKCM	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.25
p.D432N	TCGA-DA-A1I0	SKCM	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.D432N	DO37719	SKCM	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.R4573Q	TCGA-E9-A5UO	BRCA	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	TCGA-EI-6917	READ	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	DO44105	BRCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	DO230334	COCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	DO229010	COCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	DO36881	READ	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	SIDM00615	Hepatocellular Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	SIDM00465	Ovarian Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	ACH-000217	Liver Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	ACH-000865	Esophageal Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	ACH-002183	Ovarian Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	JHH-6	liver	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	KYSE-450	oesophagus	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.R4573Q	OVMIU	ovary	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.7329
p.P4587S	TCGA-EE-A2GD	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.1389
p.P4587S	DO37603	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.1389
p.G4548E	TCGA-EE-A3J8	SKCM	TCGA	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1389
p.G4548E	DO47276	SKCM	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.1389
p.K4588N	TCGA-EO-A3AV	UCEC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation substituting flanking lysine	0.2222
p.K4588N	DO52412	UCEC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation substituting flanking lysine	0.2222
p.D4580N	TCGA-FW-A3R5	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.5821
p.D4580N	DO233679	GACA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.5821
p.D4580N	DO37406	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.5821
p.N4574K	TCGA-HC-A632	PRAD	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.5806
p.N4574K	DO49823	PRAD	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.5806
p.E4584D	TCGA-HD-7753	HNSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.2222
p.E4584D	DO14614	HNSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.2222
p.D4580A	TCGA-HD-A6HZ	HNSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.6682
p.D4580A	DO49998	HNSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.6682
p.G410V	TCGA-L9-A444	LUAD	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0833
p.G410V	DO26015	LUAD	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0833
p.M4567T	TCGA-N9-A4Q7	UCS	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.1944
p.S431F	TCGA-R5-A805	STAD	TCGA	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.S431F	DO222346	STAD	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.Y4541H	TCGA-VQ-A8P2	STAD	TCGA	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.7229
p.Y4541H	DO51761	STAD	ICGC	PPIY	ITCH	4538:4541	Mutation altering degron motif	0.7229
p.G4569E	DO222973	BTCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25
p.K4589I	DO223548	CLLE	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation substituting flanking lysine	0.1944
p.Q412H	DO222276	GACA	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.T429P	DO233170	GACA	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1944
p.L4565S	DO233760	GACA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.1389
p.H415Y	DO50819	LIRI	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.2222
p.H415Y	DO48719	LIRI	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.2222
p.Y4566C	DO48677	LIRI	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.1667
p.L4542I	DO230950	LUSC	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.L4542I	DO224638	LUSC	ICGC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.D4568N	DO222678	MELA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.2222
p.S4575F	DO222837	MELA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.6871
p.G418V	DO37267	READ	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.3056
p.G418D	DO229502	SKCA	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.3056
p.A428E	DO229234	THCA	ICGC	ITVFED	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.2222
p.K4588T	SIDM02059	Colorectal Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation substituting flanking lysine	0.2222
p.S4578I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.623
p.S4578I	ACH-000945	Lung Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.623
p.S4578I	NCI-H650	lung	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation altering degron motif	0.623
p.A4537E	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537E	ACH-000729	Lung Cancer	CCLE	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.A4537E	NCI-H1963	lung	COSMIC	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.3056
p.P4534T	ACH-000700	Lung Cancer	CCLE	PPIY	ITCH	4538:4541	Mutation rewiring degron network	0.2222
p.G4569R	ACH-001568	Skin Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	4572:4580	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP1B

UniProt ID: Q9NZR2

Entrez ID: 53353

Protein name: Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP1B in