DegronMD

Uniprot ID: Q9NZR2

Source protein: Low-density lipoprotein receptor-related protein 1B

Source gene: LRP1B

Class: LIG_APCC_ABBA_1

Location: 419:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.691

ASA_SCORE: 42.4833

COIL: 0.3505

CONS_SCORE: 0.4851

DSS_SCORE: 0.0478

HELIX: 0.0057

FCONS_SCORE: 1.3687

RIG_SCORE: 0.9604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R414K	TCGA-05-4424	LUAD	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1944
p.R414K	DO23672	LUAD	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1944
p.D432E	TCGA-22-1011	LUSC	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1111
p.D432E	DO26426	LUSC	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1111
p.N430I	TCGA-85-8481	LUSC	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1667
p.N430I	DO45465	LUSC	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1667
p.L416I	TCGA-AJ-A3EL	UCEC	TCGA	ITVFED	LIG_APCC_ABBA_1	0.25
p.L416I	TCGA-BR-4257	STAD	TCGA	ITVFED	LIG_APCC_ABBA_1	0.25
p.L416I	DO38683	STAD	ICGC	ITVFED	LIG_APCC_ABBA_1	0.25
p.L416I	DO41542	UCEC	ICGC	ITVFED	LIG_APCC_ABBA_1	0.25
p.S431Y	TCGA-AX-A0J0	UCEC	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1389
p.S431Y	DO41133	UCEC	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1389
p.D432N	TCGA-DA-A1I0	SKCM	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1111
p.D432N	DO37719	SKCM	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1111
p.G410V	TCGA-L9-A444	LUAD	TCGA	ITVFED	LIG_APCC_ABBA_1	0.0833
p.G410V	DO26015	LUAD	ICGC	ITVFED	LIG_APCC_ABBA_1	0.0833
p.S431F	TCGA-R5-A805	STAD	TCGA	ITVFED	LIG_APCC_ABBA_1	0.1389
p.S431F	DO222346	STAD	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1389
p.Q412H	DO222276	GACA	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1389
p.T429P	DO233170	GACA	ICGC	ITVFED	LIG_APCC_ABBA_1	0.1944
p.H415Y	DO50819	LIRI	ICGC	ITVFED	LIG_APCC_ABBA_1	0.2222
p.H415Y	DO48719	LIRI	ICGC	ITVFED	LIG_APCC_ABBA_1	0.2222
p.G418V	DO37267	READ	ICGC	ITVFED	LIG_APCC_ABBA_1	0.3056
p.G418D	DO229502	SKCA	ICGC	ITVFED	LIG_APCC_ABBA_1	0.3056
p.A428E	DO229234	THCA	ICGC	ITVFED	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	LIG_APCC_ABBA_1	419:424	ITVFED	APC,CDC20,FZR1	0.691	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons