DegronMD

Uniprot ID: Q9NZR2

Source protein: Low-density lipoprotein receptor-related protein 1B

Source gene: LRP1B

Class: DEG_APCC_DBOX_1

Location: 4572:4580

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5899

ASA_SCORE: 64.9222

COIL: 0.6896

CONS_SCORE: 0.3041

DSS_SCORE: 0.3861

HELIX: 0.2543

FCONS_SCORE: 0.7014

RIG_SCORE: 0.751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G4569W	TCGA-55-8204	LUAD	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.25
p.G4569W	TCGA-WE-A8ZT	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.25
p.G4569W	DO45322	LUAD	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.25
p.G4569W	DO51290	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.25
p.R4573L	TCGA-58-A46M	LUSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.8428
p.R4573L	DO45485	LUSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.8428
p.E4581G	TCGA-AG-3592	READ	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.3056
p.E4581G	DO37308	READ	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.3056
p.R4573Q	TCGA-E9-A5UO	BRCA	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	TCGA-EI-6917	READ	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	DO44105	BRCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	DO230334	COCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	DO229010	COCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	DO36881	READ	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	SIDM00615	Hepatocellular Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	SIDM00465	Ovarian Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	ACH-000217	Liver Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	ACH-000865	Esophageal Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	ACH-002183	Ovarian Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	JHH-6	liver	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	KYSE-450	oesophagus	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.R4573Q	OVMIU	ovary	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	0.7329
p.P4587S	TCGA-EE-A2GD	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.1389
p.P4587S	DO37603	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.1389
p.K4588N	TCGA-EO-A3AV	UCEC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.K4588N	DO52412	UCEC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.D4580N	TCGA-FW-A3R5	SKCM	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.5821
p.D4580N	DO233679	GACA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.5821
p.D4580N	DO37406	SKCM	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.5821
p.N4574K	TCGA-HC-A632	PRAD	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.5806
p.N4574K	DO49823	PRAD	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.5806
p.E4584D	TCGA-HD-7753	HNSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.E4584D	DO14614	HNSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.D4580A	TCGA-HD-A6HZ	HNSC	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.6682
p.D4580A	DO49998	HNSC	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.6682
p.M4567T	TCGA-N9-A4Q7	UCS	TCGA	CRNSLGSVD	DEG_APCC_DBOX_1	0.1944
p.G4569E	DO222973	BTCA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.25
p.K4589I	DO223548	CLLE	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.1944
p.L4565S	DO233760	GACA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.1389
p.Y4566C	DO48677	LIRI	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.1667
p.D4568N	DO222678	MELA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.S4575F	DO222837	MELA	ICGC	CRNSLGSVD	DEG_APCC_DBOX_1	0.6871
p.K4588T	SIDM02059	Colorectal Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	0.2222
p.S4578I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	CRNSLGSVD	DEG_APCC_DBOX_1	0.623
p.S4578I	ACH-000945	Lung Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	0.623
p.S4578I	NCI-H650	lung	COSMIC	CRNSLGSVD	DEG_APCC_DBOX_1	0.623
p.G4569R	ACH-001568	Skin Cancer	CCLE	CRNSLGSVD	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRNSLGSVD

Degron related mutations and impact score

Drug responses associated with LRP1B mutations

All proteins holding degron of CRNSLGSVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	DEG_APCC_DBOX_1	4572:4580	CRNSLGSVD	APC,CDC20,FZR1	0.5899	More...