DegronMD - Q08495(DMTN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R84C	TCGA-12-0775	GBM	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.R84C	TCGA-EO-A22U	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.R84C	DO14133	GBM	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.R84C	DO43755	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.V153M	TCGA-29-1783	OV	TCGA	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1667
p.V153M	DO28222	OV	ICGC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1667
p.V153M	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1667
p.V153M	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1667
p.E312Q	TCGA-34-5929	LUSC	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0556
p.E312Q	DO26659	LUSC	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0556
p.H277R	TCGA-53-7624	LUAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.7133
p.H277R	DO25058	LUAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.7133
p.D272N	TCGA-55-8514	LUAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.5821
p.D272N	DO23616	LUAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.5821
p.P291S	TCGA-AA-3672	COAD	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.25
p.P291S	DO9010	COAD	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.25
p.R268C	TCGA-AJ-A3EK	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.25
p.R268C	DO41584	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.25
p.P262L	TCGA-AP-A059	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0833
p.P262L	TCGA-B5-A3FC	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0833
p.P262L	DO41871	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0833
p.P262L	DO41361	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0833
p.D225N	TCGA-AP-A0LM	UCEC	TCGA	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation altering degron motif	0.6932
p.D225N	DO23324	LINC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation altering degron motif	0.6932
p.D225N	DO43306	UCEC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation altering degron motif	0.6932
p.I263F	TCGA-AR-A1AV	BRCA	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.I263F	DO4659	BRCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.S92P	TCGA-B0-4710	KIRC	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7863
p.S92P	DO20633	KIRC	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7863
p.H277Y	TCGA-D3-A2JH	SKCM	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.6118
p.H277Y	DO47263	SKCM	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.6118
p.L301P	TCGA-EE-A2GC	SKCM	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7582
p.L301P	DO37839	SKCM	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7582
p.S85L	TCGA-EL-A3CT	THCA	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation blocking phosphorylation signal	0.6944
p.S85L	DO48113	THCA	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation blocking phosphorylation signal	0.6944
p.R300W	TCGA-EO-A3AZ	UCEC	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7523
p.R300W	DO233652	GACA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7523
p.R300W	DO50078	UCEC	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7523
p.P145L	TCGA-HT-7677	LGG	TCGA	PPIY	ITCH	144:147	Mutation altering degron motif	0.7582
p.P145L	DO22283	LGG	ICGC	PPIY	ITCH	144:147	Mutation altering degron motif	0.7582
p.R80C	TCGA-LN-A7HW	ESCA	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.R80C	TCGA-RS-A6TP	HNSC	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.R80C	DO219062	HNSC	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.D272A	TCGA-N5-A4RM	UCS	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.6682
p.E218Q	TCGA-UY-A9PH	BLCA	TCGA	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1944
p.E218Q	DO223594	BLCA	ICGC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1944
p.T267P	TCGA-VQ-A8PP	STAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2222
p.T267P	DO51774	STAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2222
p.S92F	TCGA-VQ-A91K	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.9093
p.S92F	DO51785	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.9093
p.T284M	DO222955	BTCA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0556
p.T284M	DO222955	BTCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1667
p.T267A	DO8264	COAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2222
p.Q302K	DO230334	COCA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.5833
p.Q302K	SIDM00530	Esophageal Carcinoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.5833
p.Q302K	SIDM00245	Small Cell Lung Carcinoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.5833
p.R84H	DO233261	GACA	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.G294D	DO228193	LICA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6087
p.G154R	DO231958	LICA	ICGC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1389
p.V99L	DO229006	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1389
p.P275S	DO229179	LMS	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.6752
p.P144R	DO230942	LUSC	ICGC	PPIY	ITCH	144:147	Mutation altering degron motif	0.7512
p.P144R	DO224589	LUSC	ICGC	PPIY	ITCH	144:147	Mutation altering degron motif	0.7512
p.P136Q	DO229164	NKTL	ICGC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.1111
p.L261F	DO50727	ORCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0556
p.R82L	DO227557	ORCA	ICGC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1667
p.R236C	SIDM02013	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.R236C	SIDM01169	Ovarian Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.R236C	ACH-000885	Ovarian Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.R236C	TOV-21G	ovary	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.E229D	SIDM00353	Other Sarcomas	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.3056
p.E229D	ACH-000505	Sarcoma	CCLE	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.3056
p.E229D	RKN	ovary	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.3056
p.A292T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.A292T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.G214R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.0833
p.G214R	TE-4	oesophagus	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.0833
p.M230V	SIDM00537	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.2778
p.M230V	GP5d	large intestine	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.2778
p.P93R	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.P93R	ACH-000875	Lung Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.P93R	NCI-H2347	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.L290F	SIDM01228	Melanoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2222
p.L290F	ACH-000931	Skin Cancer	CCLE	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2222
p.L290F	CHL-1	skin	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2222
p.R236H	SIDM01609	Endometrial Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.R236H	ACH-000972	Endometrial/Uterine Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation rewiring degron network	0.1111
p.R264Q	SIDM00497	Colorectal Carcinoma	GDSC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1389
p.N142K	ACH-000087	Bone Cancer	CCLE	PPIY	ITCH	144:147	Mutation rewiring degron network	0.2778
p.N142K	SK-ES-1	bone	COSMIC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.2778
p.R224Q	ACH-000683	Colon/Colorectal Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	223:228	Mutation altering degron motif	0.7329
p.A135S	ACH-000760	Brain Cancer	CCLE	PPIY	ITCH	144:147	Mutation rewiring degron network	0.0833
p.T83I	ACH-000967	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1944
p.T83I	ACH-001199	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1944
p.T83I	SNU-C2B	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1944
p.R290W	ACH-000999	Colon/Colorectal Cancer	CCLE	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2222
p.R290W	SNU-1040	large intestine	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2222
p.T134A	NCI-SNU-1	stomach	COSMIC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.0556
p.T134A	SLVL	haematopoietic and lymphoid tissue	COSMIC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.0556
p.L265F	CHL-1	skin	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1667
p.N157K	SK-ES-1	bone	COSMIC	PPIY	ITCH	144:147	Mutation rewiring degron network	0.0556
p.A267T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2222
p.S80L	Hs939-T	skin	COSMIC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.T98I	SNU-C2B	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1667
p.R285K	KNS-81-FD	central nervous system	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5278
p.R285K	KNS-81-FD	central nervous system	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	271:278	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for DMTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMTN

UniProt ID: Q08495

Entrez ID: 2039

Protein name: Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMTN in