DegronMD

Uniprot ID: Q08495

Source protein: Dematin

Source gene: DMTN

Class: DEG_APCC_DBOX_1

Location: 294:302

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9675

ASA_SCORE: 55.6556

COIL: 0.6312

CONS_SCORE: 0.5471

DSS_SCORE: 0.6187

HELIX: 0.1916

FCONS_SCORE: 1.1634

RIG_SCORE: 0.7059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E312Q	TCGA-34-5929	LUSC	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	0.0556
p.E312Q	DO26659	LUSC	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.0556
p.P291S	TCGA-AA-3672	COAD	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	0.25
p.P291S	DO9010	COAD	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.25
p.L301P	TCGA-EE-A2GC	SKCM	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	0.7582
p.L301P	DO37839	SKCM	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.7582
p.R300W	TCGA-EO-A3AZ	UCEC	TCGA	GRTTLSRLQ	DEG_APCC_DBOX_1	0.7523
p.R300W	DO233652	GACA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.7523
p.R300W	DO50078	UCEC	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.7523
p.T284M	DO222955	BTCA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.0556
p.Q302K	DO230334	COCA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.5833
p.Q302K	SIDM00530	Esophageal Carcinoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.5833
p.Q302K	SIDM00245	Small Cell Lung Carcinoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.5833
p.G294D	DO228193	LICA	ICGC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.6087
p.A292T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2778
p.A292T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2778
p.L290F	SIDM01228	Melanoma	GDSC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2222
p.L290F	ACH-000931	Skin Cancer	CCLE	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2222
p.L290F	CHL-1	skin	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2222
p.R290W	ACH-000999	Colon/Colorectal Cancer	CCLE	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2222
p.R290W	SNU-1040	large_intestine	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.2222
p.R285K	KNS-81-FD	central_nervous_system	COSMIC	GRTTLSRLQ	DEG_APCC_DBOX_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08495	Dematin	DEG_APCC_DBOX_1	294:302	GRTTLSRLQ	APC,CDC20,FZR1	0.9675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons