DegronMD

Uniprot ID: Q08495

Source protein: Dematin

Source gene: DMTN

Class: DEG_SCF_FBW7_1

Location: 271:278

E3 ligase: FBXW7

DEGRON score: 0.9503

ASA_SCORE: 88.475

COIL: 0.8006

CONS_SCORE: 0.6039

DSS_SCORE: 0.6527

HELIX: 0.1005

FCONS_SCORE: 1.1358

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H277R	TCGA-53-7624	LUAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.7133
p.H277R	DO25058	LUAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.7133
p.D272N	TCGA-55-8514	LUAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.5821
p.D272N	DO23616	LUAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.5821
p.R268C	TCGA-AJ-A3EK	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.25
p.R268C	DO41584	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.25
p.P262L	TCGA-AP-A059	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.0833
p.P262L	TCGA-B5-A3FC	UCEC	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.0833
p.P262L	DO41871	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.0833
p.P262L	DO41361	UCEC	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.0833
p.I263F	TCGA-AR-A1AV	BRCA	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.1111
p.I263F	DO4659	BRCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.1111
p.H277Y	TCGA-D3-A2JH	SKCM	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.6118
p.H277Y	DO47263	SKCM	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.6118
p.D272A	TCGA-N5-A4RM	UCS	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.6682
p.T267P	TCGA-VQ-A8PP	STAD	TCGA	PDRTPFHT	DEG_SCF_FBW7_1	0.2222
p.T267P	DO51774	STAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.2222
p.T284M	DO222955	BTCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.1667
p.T267A	DO8264	COAD	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.2222
p.P275S	DO229179	LMS	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.6752
p.L261F	DO50727	ORCA	ICGC	PDRTPFHT	DEG_SCF_FBW7_1	0.0556
p.R264Q	SIDM00497	Colorectal Carcinoma	GDSC	PDRTPFHT	DEG_SCF_FBW7_1	0.1389
p.L265F	CHL-1	skin	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	0.1667
p.A267T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	0.2222
p.R285K	KNS-81-FD	central_nervous_system	COSMIC	PDRTPFHT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08495	Dematin	DEG_SCF_FBW7_1	271:278	PDRTPFHT	FBXW7	0.9503	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons